Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Iglc1tm2Ust mutation
(0 available);
any
Iglc1 mutation
(4 available)
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hematopoietic system
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• lambda1-val B cell numbers are reduced 4-fold compared to in wild-type mice
• the total number of B cells is reduced relative to wild-type
• lambda2, 3 B cells are decreased relative to wild-type mice
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immune system
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• lambda1-val B cell numbers are reduced 4-fold compared to in wild-type mice
• the total number of B cells is reduced relative to wild-type
• lambda2, 3 B cells are decreased relative to wild-type mice
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Allelic Composition |
Iglc1tm2Ust/Iglc1+
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Genetic Background |
involves: 129S7/SvEvBrd * C57BL/6J |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Iglc1tm2Ust mutation
(0 available);
any
Iglc1 mutation
(4 available)
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hematopoietic system
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• VJ lamda 1 rearrangement is enhanced, however most of the rearrangements are nonproductive
• frequency of productive lamda 1 rearrangements is reduced about 10-fold
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immune system
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• VJ lamda 1 rearrangement is enhanced, however most of the rearrangements are nonproductive
• frequency of productive lamda 1 rearrangements is reduced about 10-fold
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igktm1Dhu mutation
(1 available);
any
Igk mutation
(25 available)
Iglc1tm2Ust mutation
(0 available);
any
Iglc1 mutation
(4 available)
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immune system
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• B-1a B cell numbers are increased relative to in Igktm1Dhu homozygotes and 4- to 8-fold higher and 3.5 times more in the spleen and peritoneal cavity, respectively, relative to Igktm1Dhu Igl-C1tm1Ust homozygotes
• B-1a B cells comprise 50% of peritoneal lymphocytes compared to only 14.5% in Igktm1Dhu homozygotes and 18.5% in Igktm1Dhu Igl-C1tm1Ust homozygotes
• the ratio of B1 to B2 cells is increased relative to Igktm1Dhu homozygotes
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hematopoietic system
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• B-1a B cell numbers are increased relative to in Igktm1Dhu homozygotes and 4- to 8-fold higher and 3.5 times more in the spleen and peritoneal cavity, respectively, relative to Igktm1Dhu Igl-C1tm1Ust homozygotes
• B-1a B cells comprise 50% of peritoneal lymphocytes compared to only 14.5% in Igktm1Dhu homozygotes and 18.5% in Igktm1Dhu Igl-C1tm1Ust homozygotes
• the ratio of B1 to B2 cells is increased relative to Igktm1Dhu homozygotes
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igktm1Dhu mutation
(1 available);
any
Igk mutation
(25 available)
Iglc1tm2Ust mutation
(0 available);
any
Iglc1 mutation
(4 available)
|
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immune system
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• generation of immature lamda1 B cells in the bone marrow and their continued maturation to mature B cells in the spleen are defective
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• number of immature lamda 1 B cells is decreased 2- to 3-fold in the bone marrow
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• 3-fold decrease in lamda 1 transitional type 1 (T1) B cells
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• 10-fold decrease in the number of transitional 2 (T2) lamda 1 B cells
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• reduced numbers of immature lambda 1 B cells in bone marrow and reduced numbers of mature lambda 1 B cells in spleen
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• 6-fold decrease in the number of mature lamda 1 B cells
• number of recirculating mature lamda 1 B cells in the bone marrow is decreased 7- to 20-fold
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• decrease in marginal zone lamda 1 B cells
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hematopoietic system
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• generation of immature lamda1 B cells in the bone marrow and their continued maturation to mature B cells in the spleen are defective
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• number of immature lamda 1 B cells is decreased 2- to 3-fold in the bone marrow
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• 3-fold decrease in lamda 1 transitional type 1 (T1) B cells
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• 10-fold decrease in the number of transitional 2 (T2) lamda 1 B cells
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• reduced numbers of immature lambda 1 B cells in bone marrow and reduced numbers of mature lambda 1 B cells in spleen
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• 6-fold decrease in the number of mature lamda 1 B cells
• number of recirculating mature lamda 1 B cells in the bone marrow is decreased 7- to 20-fold
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• decrease in marginal zone lamda 1 B cells
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Iglc1tm2Ust mutation
(0 available);
any
Iglc1 mutation
(4 available)
Ptpn6me-v mutation
(3 available);
any
Ptpn6 mutation
(47 available)
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immune system
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• lambda1-val B cell numbers are reduced 14-fold compared to in wild-type mice
• the total number of B cells is reduced relative to wild-type
• lambda2, 3 B cells are decreased relative to wild-type mice to a greater extent than in a Ptpn6+ background
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hematopoietic system
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• lambda1-val B cell numbers are reduced 14-fold compared to in wild-type mice
• the total number of B cells is reduced relative to wild-type
• lambda2, 3 B cells are decreased relative to wild-type mice to a greater extent than in a Ptpn6+ background
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