All Phenotypes Dnmt1<tm3Jae> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dnmt1^tm3Jae
targeted mutation 3, Rudolf Jaenisch
MGI:2657151

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnmt1^tm3Jae/Dnmt1^tm3Jae	involves: 129S4/SvJae * BALB/c	MGI:2657157
ht2	Dnmt1^tm3Jae/Dnmt1^tm2Enl	involves: 129S4/SvJae * BALB/c	MGI:2657159

Allelic Composition	Dnmt1^tm3Jae/Dnmt1^tm3Jae
Genetic Background	involves: 129S4/SvJae * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1^tm3Jae mutation (1 available); any Dnmt1 mutation (112 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:83179 )

• mice were viable and normal in size

• normal methylation and expression patterns of imprinted genes

Allelic Composition	Dnmt1^tm3Jae/Dnmt1^tm2Enl
Genetic Background	involves: 129S4/SvJae * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1^tm2Enl mutation (1 available); any Dnmt1 mutation (112 available)
Dnmt1^tm3Jae mutation (1 available); any Dnmt1 mutation (112 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:82979 )

• 80% developed aggressive thymic tumors by 4 to 8 months of age

• high frequency of chromosome 15 trisomy

growth/size/body

postnatal growth retardation ( J:82979 )

• neonates were approximately 70% the weight of Dnmt1^tm2Enl heterozygotes

reproductive system

reproductive system phenotype ( J:82979 )

N	• mice were fertile

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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