All Phenotypes Tg(Lck-icre)3779Nik MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Lck-icre)3779Nik
transgene insertion 3779, Nigel Killeen
MGI:2655492

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd4^tm1Litt/Cd4^tm1Nik Tg(Lck-icre)3779Nik/0	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2	MGI:2655529
cn2	Gt(ROSA)26Sor^tm1Jus/Gt(ROSA)26Sor⁺ Tg(Lck-icre)3779Nik/0	involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA/2	MGI:5517426
cn3	Ppp2r2d^em1Gct/Ppp2r2d^em1Gct Tg(Lck-icre)3779Nik/0	involves: C57BL/6 * DBA/2	MGI:6740222

Allelic Composition	Cd4^tm1Litt/Cd4^tm1Nik Tg(Lck-icre)3779Nik/0
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4^tm1Litt mutation (2 available); any Cd4 mutation (85 available)
Cd4^tm1Nik mutation (2 available); any Cd4 mutation (85 available)
Tg(Lck-icre)3779Nik mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

abnormal CD4-positive, alpha-beta T cell physiology ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

hematopoietic system

decreased T cell proliferation ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

abnormal CD4-positive, alpha-beta T cell physiology ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

cellular

decreased T cell proliferation ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

Allelic Composition	Gt(ROSA)26Sor^tm1Jus/Gt(ROSA)26Sor⁺ Tg(Lck-icre)3779Nik/0
Genetic Background	involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Jus mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(Lck-icre)3779Nik mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:202090 )

N	• mice exhibit normal T cell differentiation

neoplasm

neoplasm ( J:202090 )

N	• mice do not develop leukemia

Allelic Composition	Ppp2r2d^em1Gct/Ppp2r2d^em1Gct Tg(Lck-icre)3779Nik/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp2r2d^em1Gct mutation (0 available); any Ppp2r2d mutation (310 available)
Tg(Lck-icre)3779Nik mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:308373 )

N	• normal T cell subset percentages and absolute numbers in thymus and spleen • normal percentage of apoptotic double-negative and double-positive thymocytes after CD3 antibody stimulation

abnormal regulatory T cell physiology ( J:308373 )

• increased suppressive activity

immune system

abnormal regulatory T cell physiology ( J:308373 )

• increased suppressive activity

increased interleukin-2 secretion ( J:308373 )

• increased production in stimulated spleen CD4+ and CD8+ T cells

behavior/neurological

behavior/neurological phenotype ( J:308373 )

N	• normal behavior

growth/size/body

growth/size/body region phenotype ( J:308373 )

N	• normal size, no gross abnormalities

mortality/aging

mortality/aging ( J:308373 )

N

• viable

reproductive system

reproductive system phenotype ( J:308373 )

N

• fertile

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