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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(F3)1Nmk
transgene insertion 1, Nigel Mackman
MGI:2654474
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		F3tm1Dco/F3tm1Dco
Tg(F3)1Nmk/0 		B6.Cg-F3tm1Dco Tg(F3)1Nmk MGI:4822465
cx2
 		F3tm1Dco/F3tm1Dco
Thbdtm2Rdr/Thbdtm2Rdr
Tg(F3)1Nmk/0 		involves: 129/Sv * 129S2/SvPas * BALB/c * C57BL/6 MGI:3687574
cx3
 		F3tm1Dco/F3tm1Dco
Tg(F3)1Nmk/0 		involves: 129/Sv * BALB/c * C57BL/6 MGI:2654490
cx4
 		F3tm1Dco/F3tm1Dco
Procrtm1Cte/Procrtm1Cte
Tg(F3)1Nmk/0 		involves: 129S7/SvEvBrd * BALB/c * Black Swiss * C57BL/6 * FVB/N MGI:3702952
cx5
 		Procrtm1Cte/Procrtm1Cte
Tg(F3)1Nmk/0 		involves: 129S7/SvEvBrd * BALB/c * C57BL/6 MGI:3702957
cx6
 		F3tm1Dco/F3tm1Dco
Tg(F3)1Nmk/? 		involves: BALB/c * C57BL/6 MGI:3826856


Genotype
MGI:4822465
cx1
Allelic
Composition		 F3tm1Dco/F3tm1Dco
Tg(F3)1Nmk/0
Genetic
Background		 B6.Cg-F3tm1Dco Tg(F3)1Nmk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F3tm1Dco mutation (0 available); any F3 mutation (24 available)
Tg(F3)1Nmk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to induced morbidity/mortality ( J:88245 )
• when challenged with lipopolysaccharide (LPS), mutants exhibit prolonged survival and decreased mortality compared to controls

homeostasis/metabolism
abnormal blood coagulation ( J:88245 )
• LPS induced formation of thrombin-antithrombin-III complexes is reduced compared to controls, indicating that activation of coagulation is attenuated
abnormal interleukin level ( J:88245 )
• IL-6 expression is reduced at 8-12 hours after LPS challenge

immune system
abnormal interleukin level ( J:88245 )
• IL-6 expression is reduced at 8-12 hours after LPS challenge
decreased susceptibility to endotoxin shock ( J:88245 )
• when challenged with lipopolysaccharide (LPS), mutants exhibit prolonged survival and decreased mortality compared to controls




Genotype
MGI:3687574
cx2
Allelic
Composition		 F3tm1Dco/F3tm1Dco
Thbdtm2Rdr/Thbdtm2Rdr
Tg(F3)1Nmk/0
Genetic
Background		 involves: 129/Sv * 129S2/SvPas * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F3tm1Dco mutation (0 available); any F3 mutation (24 available)
Tg(F3)1Nmk mutation (0 available)
Thbdtm2Rdr mutation (0 available); any Thbd mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:82224 )
N
• mutant embryos develop normally beyond E10.5 and are viable to birth

embryo
placenta hemorrhage ( J:82224 )
• at E10.5, mutant embryos exhibit bleeding in the placental labyrinth, not caused by thrombomodulin deficiency but characteristic of embryos with low F3 activity

cardiovascular system
placenta hemorrhage ( J:82224 )
• at E10.5, mutant embryos exhibit bleeding in the placental labyrinth, not caused by thrombomodulin deficiency but characteristic of embryos with low F3 activity




Genotype
MGI:2654490
cx3
Allelic
Composition		 F3tm1Dco/F3tm1Dco
Tg(F3)1Nmk/0
Genetic
Background		 involves: 129/Sv * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F3tm1Dco mutation (0 available); any F3 mutation (24 available)
Tg(F3)1Nmk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:82528 )
• unlike homozygous null embryos, rescued mice carrying the human minigene and expressing low (<1%) of activity survive embryonic lethality and display normal development and fertility, with no signs of a bleeding diathesis and normal viability up to 7 months of age




Genotype
MGI:3702952
cx4
Allelic
Composition		 F3tm1Dco/F3tm1Dco
Procrtm1Cte/Procrtm1Cte
Tg(F3)1Nmk/0
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/c * Black Swiss * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F3tm1Dco mutation (0 available); any F3 mutation (24 available)
Procrtm1Cte mutation (0 available); any Procr mutation (15 available)
Tg(F3)1Nmk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:119529 )
N
• mice are born at expected frequency and survive at least 8 months




Genotype
MGI:3702957
cx5
Allelic
Composition		 Procrtm1Cte/Procrtm1Cte
Tg(F3)1Nmk/0
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Procrtm1Cte mutation (0 available); any Procr mutation (15 available)
Tg(F3)1Nmk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:119529 )
• no embryos with this genotype are found at birth




Genotype
MGI:3826856
cx6
Allelic
Composition		 F3tm1Dco/F3tm1Dco
Tg(F3)1Nmk/?
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F3tm1Dco mutation (0 available); any F3 mutation (24 available)
Tg(F3)1Nmk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiac fibrosis ( J:137921 )
• hemosiderin deposition and fibrosis after 6 months of age




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory