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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tfdp1tm1Lili
targeted mutation 1, Lili Yamasaki
MGI:2653309
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tfdp1tm1Lili/Tfdp1tm1Lili involves: 129S2/SvPas * C57BL/6 MGI:2653310
ht2
 		Tfdp1tm1Lili/Tfdp1+ involves: 129S2/SvPas * C57BL/6 MGI:3028919
cx3
 		Tfdp1tm1Lili/Tfdp1tm1Lili
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129S2/SvPas * C57BL/6 MGI:2653311
cx4
 		Tfdp1tm1Lili/Tfdp1+
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129S2/SvPas * C57BL/6 MGI:2653312


Genotype
MGI:2653310
hm1
Allelic
Composition		 Tfdp1tm1Lili/Tfdp1tm1Lili
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfdp1tm1Lili mutation (1 available); any Tfdp1 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:81580 )
• death by E12.5, with only 1 in 3 viable at E11.5

embryo
embryonic growth retardation ( J:81580 )
• substantial variation in degree, observed between E9.5 and E11.5
• developmental delay with regard to morphological stage criteria
decreased embryo size ( J:81580 )
• evident at E9.5
small ectoplacental cone ( J:81580 )
• evident at E8.5

growth/size/body
embryonic growth retardation ( J:81580 )
• substantial variation in degree, observed between E9.5 and E11.5
• developmental delay with regard to morphological stage criteria
decreased embryo size ( J:81580 )
• evident at E9.5




Genotype
MGI:3028919
ht2
Allelic
Composition		 Tfdp1tm1Lili/Tfdp1+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfdp1tm1Lili mutation (1 available); any Tfdp1 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:81580 )
N
• no abnormalities or increase in tumor predisposition over 9 - 12 months of observation




Genotype
MGI:2653311
cx3
Allelic
Composition		 Tfdp1tm1Lili/Tfdp1tm1Lili
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfdp1tm1Lili mutation (1 available); any Tfdp1 mutation (41 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:2653312
cx4
Allelic
Composition		 Tfdp1tm1Lili/Tfdp1+
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfdp1tm1Lili mutation (1 available); any Tfdp1 mutation (41 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:81580 )
• incomplete penetrance, ~50% survive to adulthood

nervous system
exencephaly ( J:81580 )
• observed at E13.5, and incompletely penetrant




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory