About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Krt17tm1Cou
targeted mutation 1, Pierre A Coulombe
MGI:2651542
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Krt17tm1Cou/Krt17tm1Cou B6.129S2(D2)-Krt1-17tm1Cou MGI:2651544
hm2
 		Krt17tm1Cou/Krt17tm1Cou involves: 129S2/SvPas MGI:2651545
hm3
 		Krt17tm1Cou/Krt17tm1Cou involves: 129S2/SvPas * C57BL/6 * DBA/2 MGI:2651543
cx4
 		Krt17tm1Cou/Krt17tm1Cou
Krt6a/Krt6btm1Cou/Krt6a/Krt6btm1Cou
Krt6a/Krt6btm1Cou/Krt6a/Krt6btm1Cou 		involves: 129S2/SvPas * C57BL/6 MGI:3582966


Genotype
MGI:2651544
hm1
Allelic
Composition		 Krt17tm1Cou/Krt17tm1Cou
Genetic
Background		 B6.129S2(D2)-Krt1-17tm1Cou
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt17tm1Cou mutation (0 available); any Krt17 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
alopecia ( J:82089 )
• initially fail to develop a full coat of hair
• hair phenotype improves after 3 weeks of age with recovery "peaking" at 30 days
• recovery corresponds to first postnatal anagen phase of hair cycle




Genotype
MGI:2651545
hm2
Allelic
Composition		 Krt17tm1Cou/Krt17tm1Cou
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt17tm1Cou mutation (0 available); any Krt17 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
integument phenotype ( J:82089 )
N
• no detectable skin phenotype




Genotype
MGI:2651543
hm3
Allelic
Composition		 Krt17tm1Cou/Krt17tm1Cou
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt17tm1Cou mutation (0 available); any Krt17 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal hair follicle melanin granule morphology ( J:82089 )
• aggregates of melanin pigment at points along follicle

integument
increased hair follicle apoptosis ( J:82089 )
• in some follicles, epithelial cells of matrix in hair bulbs undergo massive destruction by apoptosis
alopecia ( J:82089 )
• a subset of mutants initially fail to develop a full coat of hair
• hair phenotype improves after 3 weeks of age with recovery "peaking" at 30 days
• recovery corresponds to first postnatal anagen phase of hair cycle
brittle hair ( J:82089 )
• hair is fragile with breaks in the hair shaft
• hairs are 3-fold more likely to break when pulled than controls
abnormal hair shaft morphology ( J:82089 )
• breaks or ruptures of hair shaft above bulb region
• hair prone to breaking
abnormal hair medulla ( J:82089 )
• cell lysis and pyknotic nuclei within the lower medulla in a subset of hair follicles
abnormal hair follicle morphology ( J:82089 )
• cellular degeneration seen in all compartments of follicles and follicle length is slightly shorter
• ovoid bodies composed of multiple eosinophilic matrix epithelial cells found on the posterior aspect of some hair bulbs
• follicular alterations increase from 3 to 10 days of age
abnormal hair follicle melanin granule morphology ( J:82089 )
• aggregates of melanin pigment at points along follicle
abnormal hair follicle matrix region morphology ( J:82089 )
• in some follicles, epithelial cells of matrix in hair bulbs undergo massive destruction by apoptosis
hair follicle degeneration ( J:82089 )
• severe cases exhibit degenerating hair follicles that coexist with normal follicles
absent vibrissae ( J:82089 )
• often missing on either side of the nose in mutants with severe alopecia
abnormal hair cycle ( J:82089 )
• individual hair follicles are often at different phases of their cycle in 31 day old mutants, indicating impaired progression through the hair cycle

cellular
increased hair follicle apoptosis ( J:82089 )
• in some follicles, epithelial cells of matrix in hair bulbs undergo massive destruction by apoptosis




Genotype
MGI:3582966
cx4
Allelic
Composition		 Krt17tm1Cou/Krt17tm1Cou
Krt6a/Krt6btm1Cou/Krt6a/Krt6btm1Cou
Krt6a/Krt6btm1Cou/Krt6a/Krt6btm1Cou
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt17tm1Cou mutation (0 available); any Krt17 mutation (27 available)
Krt6a/Krt6btm1Cou mutation (0 available); any Krt6a mutation (25 available)
Krt6a/Krt6btm1Cou mutation (0 available); any Krt6b mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:95390 )
• triple homozygotes usually die between the first and fourth day after birth

craniofacial
abnormal palate morphology ( J:95390 )
• severe lysis and inflammatory changes in the epithelium of the upper palate
abnormal tongue epithelium morphology ( J:95390 )
• dorsal tongue epithelium destroyed at birth
• severe lysis and inflammatory changes

digestive/alimentary system
abnormal palate morphology ( J:95390 )
• severe lysis and inflammatory changes in the epithelium of the upper palate
abnormal tongue epithelium morphology ( J:95390 )
• dorsal tongue epithelium destroyed at birth
• severe lysis and inflammatory changes

integument
abnormal nail morphology ( J:95390 )
• cell lysis in the nail bed affecting the lowermost suprabasal layers of the epithelium

growth/size/body
abnormal palate morphology ( J:95390 )
• severe lysis and inflammatory changes in the epithelium of the upper palate
abnormal tongue epithelium morphology ( J:95390 )
• dorsal tongue epithelium destroyed at birth
• severe lysis and inflammatory changes

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
pachyonychia congenita DOID:0050449 OMIM:PS167200
 J:95390




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory