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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Apoa1tm1(APOA1)Prli
targeted mutation 1, Cinzia Parolini
MGI:2451255
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Apoa1tm1(APOA1)Prli/Apoa1tm1(APOA1)Prli involves: 129X1/SvJ * C57BL/6 MGI:2451258
ht2
 		Apoa1tm1(APOA1)Prli/Apoa1tm2(APOA1)Prli involves: 129X1/SvJ * C57BL/6J MGI:2451259


Genotype
MGI:2451258
hm1
Allelic
Composition		 Apoa1tm1(APOA1)Prli/Apoa1tm1(APOA1)Prli
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoa1tm1(APOA1)Prli mutation (0 available); any Apoa1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:81908 )
N
• total and HDL cholesterol levels are no different from controls




Genotype
MGI:2451259
ht2
Allelic
Composition		 Apoa1tm1(APOA1)Prli/Apoa1tm2(APOA1)Prli
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoa1tm1(APOA1)Prli mutation (0 available); any Apoa1 mutation (16 available)
Apoa1tm2(APOA1)Prli mutation (0 available); any Apoa1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating cholesterol level ( J:81908 )
• total cholesterol is intermediate to levels seen in Apoa1tm2(APOA1)Prli homozygotes and Apoa1tm1(APOA1)Prli homozygotes and is lower than seen in controls

liver/biliary system
abnormal liver physiology ( J:81908 )
• secretion of the human APOA1 into the medium is reduced in cultured hepatic cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory