Apoa1^{tm1(APOA1)Prli}
Targeted Allele Detail

Summary

• Symbol: Apoa1^{tm1(APOA1)Prli}
• Name: apolipoprotein A-I; targeted mutation 1, Cinzia Parolini
• MGI ID: MGI:2451255
• Synonyms: A-I k-in
• Gene: Apoa1 Location: Chr9:46139928-46141767 bp, + strand Genetic Position: Chr9, 25.36 cM, cytoband A2-A4
• Alliance: Apoa1^{tm1(APOA1)Prli} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81908
• Parent Cell Line: ESVJ (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 4 were either replaced or disrupted by the insertion of human APOA1 exons 2 through 4 via homologous recombination. Whereas murine exons 2 through 3 were replaced by the human sequence for exons 2-4, murine exon 4 was disrupted by a neomycin selection cassette. (J:81908)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apoa1 Mutation: 16 strains or lines available

References

• Original: J:81908 Parolini C, et al., Targeted replacement of mouse apolipoprotein A-I with human ApoA-I or the mutant ApoA-IMilano. Evidence of APOA-IM impaired hepatic secretion. J Biol Chem. 2003 Feb 14;278(7):4740-6
• All: 1 reference(s)