About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mettm4.1Cpo
targeted mutation 4.1, Carola Ponzetta
MGI:2450967
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Mettm2Cpo/Mettm4.1Cpo involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:2450971


Genotype
MGI:2450971
ht1
Allelic
Composition		 Mettm2Cpo/Mettm4.1Cpo
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettm2Cpo mutation (0 available); any Met mutation (81 available)
Mettm4.1Cpo mutation (0 available); any Met mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired coordination ( J:81793 )
• impaired motor coordination in thin rod test

nervous system
abnormal neuron differentiation ( J:81793 )
• 25% decrease in granule cell proliferation
reduced cerebellar foliation ( J:81793 )
• reduced or absent fissures in declival sulcus and intercrural fissure
• reduction of secondary and posterolateral fissures
small cerebellum ( J:81793 )
• cerebellar weight reduced by 20%

cellular
abnormal neuron differentiation ( J:81793 )
• 25% decrease in granule cell proliferation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory