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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hnf1atm2Ylee
targeted mutation 2, Ying-Hue Lee
MGI:2450154
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hnf1atm2Ylee/Hnf1atm2Ylee involves: 129X1/SvJ * C57BL/6J MGI:3818295
ht2
 		Hnf1atm1.1Ylee/Hnf1atm2Ylee involves: 129X1/SvJ * C57BL/6J MGI:3818296
cn3
 		Hnf1atm1.1Ylee/Hnf1atm2Ylee
Speer6-ps1Tg(Alb-cre)21Mgn/? 		involves: 129X1/SvJ * C57BL/6 * DBA MGI:3818297


Genotype
MGI:3818295
hm1
Allelic
Composition		 Hnf1atm2Ylee/Hnf1atm2Ylee
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hnf1atm2Ylee mutation (0 available); any Hnf1a mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
infertility ( J:81639 )
• both sexes




Genotype
MGI:3818296
ht2
Allelic
Composition		 Hnf1atm1.1Ylee/Hnf1atm2Ylee
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hnf1atm1.1Ylee mutation (1 available); any Hnf1a mutation (31 available)
Hnf1atm2Ylee mutation (0 available); any Hnf1a mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
infertility ( J:81639 )
• both sexes

growth/size/body
decreased body size ( J:81639 )
• growth retarded
enlarged liver ( J:81639 )

liver/biliary system
abnormal liver morphology ( J:81639 )
• vacuous hepatocytes
hepatic steatosis ( J:81639 )
• fatty liver

homeostasis/metabolism
hyperglycemia ( J:81639 )
• by 2 weeks of age




Genotype
MGI:3818297
cn3
Allelic
Composition		 Hnf1atm1.1Ylee/Hnf1atm2Ylee
Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hnf1atm1.1Ylee mutation (1 available); any Hnf1a mutation (31 available)
Hnf1atm2Ylee mutation (0 available); any Hnf1a mutation (31 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:81639 )
N
• viable and fertile

growth/size/body
growth/size/body region phenotype ( J:81639 )
N
• indistinguishable from controls

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:81639 )
N
• plasma cholesterol and triglyceride levels similar to controls
hyperglycemia ( J:81639 )
• by 2 weeks of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory