All Phenotypes Gli1<tm2Alj> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gli1^tm2Alj
targeted mutation 2, Alexandra L Joyner
MGI:2449767

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gli1^tm2Alj/Gli1^tm2Alj	involves: 129S6/SvEvTac * Black Swiss * Swiss Webster	MGI:3795684
ht2	Gli1^tm2Alj/Gli1⁺	involves: 129S6/SvEvTac * Black Swiss * Swiss Webster	MGI:3795683
cn3	En1^tm2(cre)Gld/En1⁺ Gli1^tm2Alj/Gli1^tm2Alj Gli2^tm1Alj/Gli2^tm6Alj	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster	MGI:3665567
cx4	Gli1^tm2Alj/Gli1⁺ Gli2^tm1Alj/Gli2^tm1Alj Gli3^Xt/Gli3^Xt	involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster	MGI:4414944
cx5	Gli1^tm2Alj/Gli1^tm2Alj Gli2^tm1Alj/Gli2⁺	involves: 129 * Black Swiss * Swiss Webster	MGI:2676433
cx6	Gli1^tm2Alj/Gli1⁺ Gli2^tm1Alj/Gli2^tm1Alj	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster	MGI:3795863
cx7	Gli1^tm2Alj/Gli1^tm2Alj Gli2^{tm5.1(GLI3)Alj}/Gli2^{tm5.1(GLI3)Alj}	involves: 129S6/SvEvTac * Swiss Webster	MGI:4414942
cx8	Gli1^tm2Alj/Gli1^tm2Alj Gli2^tm1Alj/Gli2^tm1Alj	involves: 129/Sv * Black Swiss * Swiss Webster	MGI:3795854
cx9	Gli1^tm2Alj/Gli1^tm2Alj Gli2^{tm3.1(Gli1)Alj}/Gli2^{tm3.1(Gli1)Alj}	involves: 129/Sv * Black Swiss * Swiss Webster	MGI:3795859

Allelic Composition	Gli1^tm2Alj/Gli1^tm2Alj
Genetic Background	involves: 129S6/SvEvTac * Black Swiss * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1^tm2Alj mutation (1 available); any Gli1 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:112460 )

N	• embryos show normal mammary gland development

Allelic Composition	Gli1^tm2Alj/Gli1⁺
Genetic Background	involves: 129S6/SvEvTac * Black Swiss * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1^tm2Alj mutation (1 available); any Gli1 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:112460 )

N	• embryos show normal mammary gland development

Allelic Composition	En1^tm2(cre)Gld/En1⁺ Gli1^tm2Alj/Gli1^tm2Alj Gli2^tm1Alj/Gli2^tm6Alj
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm2(cre)Gld mutation (0 available); any En1 mutation (32 available)
Gli1^tm2Alj mutation (1 available); any Gli1 mutation (48 available)
Gli2^tm1Alj mutation (0 available); any Gli2 mutation (169 available)
Gli2^tm6Alj mutation (1 available); any Gli2 mutation (169 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellum morphology ( J:108507 )

• cerebellum has decreased number of fissures compared to conditional Gli2 knockouts

abnormal cerebellum development ( J:108507 )

• only the five cardinal lobes of cerebellum can be discerned; other lobules do not form

abnormal cerebellar foliation ( J:108507 )

• decreased number of lobules (abnormal foliation) is observed

Allelic Composition	Gli1^tm2Alj/Gli1⁺ Gli2^tm1Alj/Gli2^tm1Alj Gli3^Xt/Gli3^Xt
Genetic Background	involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1^tm2Alj mutation (1 available); any Gli1 mutation (48 available)
Gli2^tm1Alj mutation (0 available); any Gli2 mutation (169 available)
Gli3^Xt mutation (1 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:87948 )

• progenitors for motor neurons, V1 and V2 interneurons are present but intermixed indicating abnormal spatial patterning

abnormal neuronal precursor proliferation ( J:87948 )

• increased proliferation of ventral spinal cord progenitors at E10.5

absent floor plate ( J:87948 )

• floor plate progenitors are missing

abnormal neuronal precursor cell number ( J:87948 )

• incorrect positioning and number of V0-V2 and motor neuron progenitors at E9.5

abnormal spinal cord morphology ( J:87948 )

• ventral spinal cord is expanded resulting in a wavy appearance

abnormal motor neuron morphology ( J:87948 )

• distribution of motor neurons varies at E12.5

decreased motor neuron number ( J:87948 )

• reduction in the number of differentiated motor neurons but an increase in their progenitors

abnormal ventral interneuron morphology ( J:87948 )

• absence of V3 progenitors and interneurons, however V0-V2 cells are formed

• fewer V2, V1, and V0 interneurons are seen in the hindlimb

abnormal ventral interneuron 3 morphology ( J:87948 )

• absence of V3 progenitors and interneurons, however V0-V2 cells are formed

embryo

absent floor plate ( J:87948 )

• floor plate progenitors are missing

cellular

abnormal neuron differentiation ( J:87948 )

• progenitors for motor neurons, V1 and V2 interneurons are present but intermixed indicating abnormal spatial patterning

abnormal neuronal precursor proliferation ( J:87948 )

• increased proliferation of ventral spinal cord progenitors at E10.5

Allelic Composition	Gli1^tm2Alj/Gli1^tm2Alj Gli2^tm1Alj/Gli2⁺
Genetic Background	involves: 129 * Black Swiss * Swiss Webster

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal floor plate morphology ( J:79392 )

• at E10.5, some floor plate cells have been lost

• in severely affected embryos, Foxa2-expressing cells are absent; Nkx2-2 interneurons are greatly reduced

• motor neurons occupy a more ventral position compared to controls

persistence of notochord tissue ( J:79392 )

nervous system

abnormal floor plate morphology ( J:79392 )

• at E10.5, some floor plate cells have been lost

• in severely affected embryos, Foxa2-expressing cells are absent; Nkx2-2 interneurons are greatly reduced

• motor neurons occupy a more ventral position compared to controls

respiratory system

small lung ( J:79392 )

Allelic Composition	Gli1^tm2Alj/Gli1⁺ Gli2^tm1Alj/Gli2^tm1Alj
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

small lung ( J:79392 )

• at E12.5 lungs are smaller than in wild-type

Allelic Composition	Gli1^tm2Alj/Gli1^tm2Alj Gli2^{tm5.1(GLI3)Alj}/Gli2^{tm5.1(GLI3)Alj}
Genetic Background	involves: 129S6/SvEvTac * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1^tm2Alj mutation (1 available); any Gli1 mutation (48 available)
Gli2^{tm5.1(GLI3)Alj} mutation (0 available); any Gli2 mutation (169 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent floor plate ( J:87948 )

• absence of floor plate cells throughout the anterior/posterior (A/P) axis of the spinal cord

abnormal ventral interneuron 3 morphology ( J:87948 )

• only a very small number of V3 interneurons are seen in the ventral midline of the spinal cord

embryo

absent floor plate ( J:87948 )

• absence of floor plate cells throughout the anterior/posterior (A/P) axis of the spinal cord

Allelic Composition	Gli1^tm2Alj/Gli1^tm2Alj Gli2^tm1Alj/Gli2^tm1Alj
Genetic Background	involves: 129/Sv * Black Swiss * Swiss Webster

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

impaired lung lobe morphogenesis ( J:79392 )

• lungs have only 2 lobes at E12.5

small lung ( J:79392 )

• at E12.5 and E18.5, lungs are smaller than in Gli2^tm1Alj homozygotes and much smaller than wild-type

limbs/digits/tail

polydactyly ( J:79392 )

• at E18.5 a postaxial nubbin is present on mutant limbs

Allelic Composition	Gli1^tm2Alj/Gli1^tm2Alj Gli2^{tm3.1(Gli1)Alj}/Gli2^{tm3.1(Gli1)Alj}
Genetic Background	involves: 129/Sv * Black Swiss * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1^tm2Alj mutation (1 available); any Gli1 mutation (48 available)
Gli2^{tm3.1(Gli1)Alj} mutation (0 available); any Gli2 mutation (169 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:79392 )

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