Phenotypes associated with this allele

• Allele Symbol: Psen1^tm2.1Shn
• Allele Name: targeted mutation 2.1, Jie Shen
• Allele ID: MGI:2449306
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Psen1^tm2.1Shn/Psen1^tm2.1Shn	involves: 129S4/SvJae * C57BL/6J	MGI:3777979
cn2	Psen1^tm2Shn/Psen1^tm2.1Shn Tg(Camk2a-cre)1Shn/0	involves: 129S4/SvJae * C57BL/6J * CBA	MGI:3777985

Genotype
MGI:3777979

hm1

• Allelic Composition: Psen1^tm2.1Shn/Psen1^tm2.1Shn
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:71606 )

N • phenotype is stated to be identical to that of Psen1^tm1Shn homozygotes; however no data are presented

embryo

embryo phenotype ( J:71606 )

N

growth/size/body

growth/size/body region phenotype ( J:71606 )

N

nervous system

nervous system phenotype ( J:71606 )

N

cardiovascular system

cardiovascular system phenotype ( J:71606 )

N

respiratory system

respiratory system phenotype ( J:71606 )

N

craniofacial

craniofacial phenotype ( J:71606 )

N

limbs/digits/tail

limbs/digits/tail phenotype ( J:71606 )

N

skeleton

skeleton phenotype ( J:71606 )

N

integument

integument phenotype ( J:71606 )

N

Genotype
MGI:3777985

cn2

• Allelic Composition: Psen1^tm2Shn/Psen1^tm2.1Shn; Tg(Camk2a-cre)1Shn/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA

behavior/neurological

abnormal spatial learning ( J:71606 )

• mice show mild defect in spatial learning

abnormal long-term spatial reference memory ( J:71606 )

• mice have mild but significant impairment in spatial learning and memory

• in the Morris water maze paradigm, mutants and wild-type mice show improvements in performance for the initial 7 days of training, but for the last 3-5 days, mutant performance plateaus while control mice continue to improve in finding the hidden platform

• in probe trials, mutants diplay fewer crossings of the target quadrant after 10 days of training compared to wild-type mice

• similar results are obtained when platform position is changed and test is repeated

nervous system

nervous system phenotype ( J:71606 )

N • examination of brains at P18, 20, 22, and 3 months shows no gross abnormalities

N • no increase in apoptosis is observed at any ages examined

N • normal synaptic transmission and plasticity in the Schaeffer collateral pathway are observed

amyloid beta deposits ( J:71606 )

• Abeta40 levels are reduced in cortex relative to control brains, while Abeta42 levels are elevated

homeostasis/metabolism

amyloid beta deposits ( J:71606 )

• Abeta40 levels are reduced in cortex relative to control brains, while Abeta42 levels are elevated