Phenotypes associated with this allele

• Allele Symbol: Ncoa6^tm1.1Jkr
• Allele Name: targeted mutation 1.1, Janardan K Reddy
• Allele ID: MGI:2448999
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:3810536

Genotype
MGI:3810536

hm1

• Allelic Composition: Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Developmental retardation and abnormalities in Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr E12.5 mutants

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:81217 )

• no homozygotes survive beyond E13.5

growth/size/body

abnormal palatal shelf fusion at midline ( J:81217 )

• palatal shelf fails to fuse

embryonic growth retardation ( J:81217 )

• growth retardation is seen at E11.5 and E12.5

decreased embryo size ( J:81217 )

• small size at E12.5

embryo

abnormal vitelline vasculature morphology ( J:81217 )

• yolk sac contains fewer blood vessels than wild type

embryonic growth retardation ( J:81217 )

• growth retardation is seen at E11.5 and E12.5

decreased embryo size ( J:81217 )

• small size at E12.5

abnormal placenta morphology ( J:81217 )

abnormal placenta vasculature ( J:81217 )

• most of the tortuous vessels in the placenta are enlarged, raptured and generally empty

abnormal placental labyrinth vasculature morphology ( J:81217 )

• in the placenta, maternal blood sinuses are generally absent in most areas of the labyrinth zone

abnormal trophoblast layer morphology ( J:81217 )

• trophoblast cell proliferation in the placenta is lower than in wild type

abnormal spongiotrophoblast layer morphology ( J:81217 )

• lack an organized spongiotrophoblast layer in the placenta and instead, islands of spongiotrophoblast-like cells dissociate from trophoblast giant cell layer and migrate into the labyrinth zone

abnormal embryonic hematopoiesis ( J:81217 )

• nucleated fetal erythroblasts in the placenta have irregular shaped nuclei with little cytoplasm

hematopoietic system

abnormal embryonic hematopoiesis ( J:81217 )

• nucleated fetal erythroblasts in the placenta have irregular shaped nuclei with little cytoplasm

decreased erythroid progenitor cell number ( J:81217 )

• embryonic liver shows a decrease in the number of erythroid progenitors

cardiovascular system

abnormal blood vessel morphology ( J:81217 )

• embryos show dilated leaking small vessels and few large blood vessels

abnormal placenta vasculature ( J:81217 )

• most of the tortuous vessels in the placenta are enlarged, raptured and generally empty

abnormal placental labyrinth vasculature morphology ( J:81217 )

• in the placenta, maternal blood sinuses are generally absent in most areas of the labyrinth zone

abnormal vitelline vasculature morphology ( J:81217 )

• yolk sac contains fewer blood vessels than wild type

dilated vasculature ( J:81217 )

• embryos show dilated leaking small vessels

abnormal heart morphology ( J:81217 )

• pericardial space surrounding the heart is much smaller than in wild type

abnormal myocardium layer morphology ( J:81217 )

• ventricular myocardium of embryos fails to stratify into a multilayer compact structure

thin myocardium compact layer ( J:81217 )

• at E12.5

abnormal fetal cardiomyocyte morphology ( J:81217 )

• cell-cell adhesion between cardiocytes appears defective in the compact layer

abnormal heart ventricle morphology ( J:81217 )

• ventricular myocardium of embryos fails to stratify into a multilayer compact structure

trabecula carnea hypoplasia ( J:81217 )

• trabeculation is less extensive in E12.5 mutants than in wild type

abnormal epicardium morphology ( J:81217 )

• the epicardium is separated from underlying myocardium and there is leakage of blood cells into the epicardial spaces

detached epicardium ( J:81217 )

abnormal fetal cardiomyocyte proliferation ( J:81217 )

• cell proliferation in the myocardium is reduced

craniofacial

abnormal palatal shelf fusion at midline ( J:81217 )

• palatal shelf fails to fuse

digestive/alimentary system

abnormal palatal shelf fusion at midline ( J:81217 )

• palatal shelf fails to fuse

liver/biliary system

increased hepatocyte apoptosis ( J:81217 )

• seen in embryonic liver

abnormal liver morphology ( J:81217 )

• embryonic liver contains large numbers of megakaryocytes

abnormal liver bud morphology ( J:81217 )

• only a pale primitive liver bud is seen at E12.5

decreased hepatocyte number ( J:81217 )

• embryonic liver shows a reduction in hepatocyte population

small liver ( J:81217 )

limbs/digits/tail

abnormal digit morphology ( J:81217 )

• finger separation does not occur in the distal part of the hind limb at E12.5

muscle

abnormal myocardium layer morphology ( J:81217 )

• ventricular myocardium of embryos fails to stratify into a multilayer compact structure

trabecula carnea hypoplasia ( J:81217 )

• trabeculation is less extensive in E12.5 mutants than in wild type

thin myocardium compact layer ( J:81217 )

• at E12.5

abnormal fetal cardiomyocyte proliferation ( J:81217 )

• cell proliferation in the myocardium is reduced

nervous system

abnormal brain development ( J:81217 )

• developmental abnormalities in the brain

pigmentation

abnormal eye pigmentation ( J:81217 )

• pigmented tissue is thinner in the dorsal portion of the eye at E12.5

vision/eye

abnormal eye pigmentation ( J:81217 )

• pigmented tissue is thinner in the dorsal portion of the eye at E12.5

integument

pallor ( J:81217 )

cellular

abnormal fetal cardiomyocyte proliferation ( J:81217 )

• cell proliferation in the myocardium is reduced

increased hepatocyte apoptosis ( J:81217 )

• seen in embryonic liver