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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Lck-Hhex)1Hro
transgene insertion 1, Robert Hromas
MGI:2448671
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(Lck-Hhex)1Hro/0 C3HeB/FeJ-Tg(Lck-Hhex)1Hro MGI:2655930


Genotype
MGI:2655930
tg1
Allelic
Composition		 Tg(Lck-Hhex)1Hro/0
Genetic
Background		 C3HeB/FeJ-Tg(Lck-Hhex)1Hro
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal double-negative T cell morphology ( J:80777 )
• 4.1-fold decrease in the relative percentage of CD25+CD44+ thymocytes in the CD4CD8 double-negative population of T progenitors and a concomitant 3-fold increase of CD25-CD44- cells
increased CD8-positive, alpha-beta T cell number ( J:80777 )
• 3.7-fold increase in CD8+ thymocytes
decreased leukocyte cell number ( J:80777 )
• general leukopenia due to decreased T cells in the peripheral blood
decreased lymphocyte cell number ( J:80777 )
• decrease in absolute lymphocytes
decreased T cell number ( J:80777 )
• decrease in peripheral blood T cells, especially CD8+ cells
decreased double-positive T cell number ( J:80777 )
• 1.4-fold decrease in double positive thymocytes

immune system
abnormal double-negative T cell morphology ( J:80777 )
• 4.1-fold decrease in the relative percentage of CD25+CD44+ thymocytes in the CD4CD8 double-negative population of T progenitors and a concomitant 3-fold increase of CD25-CD44- cells
increased CD8-positive, alpha-beta T cell number ( J:80777 )
• 3.7-fold increase in CD8+ thymocytes
decreased leukocyte cell number ( J:80777 )
• general leukopenia due to decreased T cells in the peripheral blood
decreased lymphocyte cell number ( J:80777 )
• decrease in absolute lymphocytes
decreased T cell number ( J:80777 )
• decrease in peripheral blood T cells, especially CD8+ cells
decreased double-positive T cell number ( J:80777 )
• 1.4-fold decrease in double positive thymocytes

endocrine/exocrine glands




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04/30/2024
MGI 6.23 		The Jackson Laboratory