Tg(Lck-Hhex)1Hro
Transgene Detail

Summary

• Symbol: Tg(Lck-Hhex)1Hro
• Name: transgene insertion 1, Robert Hromas
• MGI ID: MGI:2448671
• Synonyms: Lck/Hex
• Transgene: Tg(Lck-Hhex)1Hro Location: unknown
• Alliance: Tg(Lck-Hhex)1Hro page

Transgene origin

• Strain of Origin: C3HeB/FeJ

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Lck-Hhex)1Hro expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Hhex (MGI:96086)

• Mutation details: A full length Hhex cDNA sequence under regulatory control of a mouse Lck promoter was used for the transgene. Northern and Western blot analysis showed that transgene expression was exclusive to T lymphocytes. (J:80777)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Six transgenic founders were created. Two transgenic animals with the highest transgene copy numbers died at 16 months of age and did not breed.

References

• Original: J:80777 Mack DL, et al., Down-regulation of the myeloid homeobox protein Hex is essential for normal T-cell development. Immunology. 2002 Dec;107(4):444-51
• All: 1 reference(s)