Analysis Tools
homeostasis/metabolism
| N |
• primary hepatocytes transfected with a cre-expressing adenovirus exhibit normal glucose production
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Allele Symbol Allele Name Allele ID |
Prkaa2tm1Vio targeted mutation 1, Benoit Viollet MGI:2448466 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• primary hepatocytes transfected with a cre-expressing adenovirus exhibit normal glucose production
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• compared to wild-type mice
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• mice exhibit increased diet induced obesity compared to wild-type and Prkaa2tm1Vio/Prkaa2tm1Vio Tg(Pomc1-cre)1Gsb mice
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• mice exhibit increased diet induced obesity compared to wild-type and Prkaa2tm1Vio/Prkaa2tm1Vio Tg(Pomc1-cre)1Gsb mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when fed a high fat diet, mice gain more weight than wild-type mice
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• mice exhibit reduced resting metabolic rate compared to wild-type mice
• however, daily energy expenditure is normal
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• at 11 weeks of age, mice weight 15% more than wild-type mice
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• when fed a high fat diet, mice gain more weight than wild-type mice
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| N |
• proopiomelanocortin neurons morphology and basal function are normal
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• proopiomelanocortin neurons do not respond electrophysically to glucose as do wild-type cells
• however, the electrophysical responses of proopiomelanocortin neuron to leptin and insulin are normal
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• mice exhibit increased adipocity and total body fat compared to wild-type mice
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• mice exhibit increased compensatory feeding compared to wild-type mice after being fasted overnight
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit an increase in circulating leptin levels in a fasting mouse but leptin levels do not rise when fed unlike wild-type mice
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• in a fasting mouse but not in a fed mouse
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• in a fasting mouse but not in a fed mouse
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• endogenous glucose production is higher than in wild-type mice
• mice fail to exhibit an increase in hepatic glucose production when treated with leptin or adiponectin unlike wild-type mice
• however, mice remain sensitive to the inhibitory effects of hyperinsulinemia on gluconeogenesis and exhibit normal insulin sensitive whole body glucose turnover
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• in a fasting mouse
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• in a fasting mouse but not in a fed mouse
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• in a fasting mouse but not in a fed mouse
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 3 months of age, mice display a mild decrease in body weight compared to wild-type mice
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• agouti-related protein expressing neurons are slightly more hyperpolarized than in wild-type mice and do not respond electrophysically to glucose as do wild-type cells
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• following treatment with melanotan II, mice exhibit less food intake than similarly treated wild-type
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| N |
• despite reduction in weight, mice exhibit normal food intake, resting metabolic rate, daily energy expenditure, response to a high fat diet, leptin, glucose and adiponectin levels, and glucose and insulin tolerance
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• ABR thresholds are similar to wild-type controls, indicating rescue or delay of the premature hearing loss seen in single Tg(CAG-Tfb1m)AGsha transgenic mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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