Prkaa1^tm1.1Mfor
Targeted Allele Detail

Summary

• Symbol: Prkaa1^tm1.1Mfor
• Name: protein kinase, AMP-activated, alpha 1 catalytic subunit; targeted mutation 1.1, Marc Foretz
• MGI ID: MGI:5527231
• Synonyms: Ampkalpha1^lox
• Gene: Prkaa1 Location: Chr15:5173343-5211380 bp, + strand Genetic Position: Chr15, 1.99 cM
• Alliance: Prkaa1^tm1.1Mfor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174020
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked hygromycin cassette with a 3' loxP site was inserted downstream of exon 5, and an additional loxP site was inserted upstream of exon 4. Flp-mediated recombination removed the hygromycin cassette.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkaa1 Mutation: 42 strains or lines available

References

• Original: J:174020 Miller RA, et al., Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling. J Clin Invest. 2011 Jun 1;121(6):2518-28
• All: 33 reference(s)