Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atxn1tm2Hzo mutation
(1 available);
any
Atxn1 mutation
(50 available)
Tg(Pcp2-ATXN1*82Q)5Horr mutation
(0 available)
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behavior/neurological
nervous system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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behavior/neurological
nervous system
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• Bergmann glial proliferation
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• occasionally Purkinje cells have large clear vacuoles within their cytoplasm
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• significant loss of the Purkinje cell population
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• the dendritic arrays are abnormal
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• numerous ectopic Purkinje cells are present in the molecular layer and occasionally in the granular layer
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• shrinkage and gliosis of the molecular layer
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• gliosis in the molecular layer
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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behavior/neurological
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• develop ataxia by 12 weeks of age
(J:28932)
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• mice show a gentle swaying of the head while walking and early signs of general incoordination in the first 8-10 weeks of life, which progresses to ataxia
(J:28932)
• mutants are impaired on the accelerating rotarod at 6 and 12 weeks of age and by 30 weeks of age, are unable to perform the test
(J:166951)
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• wider hind stance that controls
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• slight reduction in cage activity
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nervous system
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• cerebellar abnormalities
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• year old mutants show severe atrophy and loss of Purkinje cells
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• atrophy of the finer dendritic branches of Purkinje cells
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• reduction in molecular layer thickness
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• mean relative height of climbing fiber terminals among Purkinje cell dendrites is reduced compared to wild-type mice, indicating compromised extension of climbing fiber terminals on Purkinje cells dendrites into the molecular layer
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Analysis Tools
