All Phenotypes Ikzf1<tm1.1(Pax5)Mbu> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ikzf1^{tm1.1(Pax5)Mbu}/Ikzf1⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:2653528
cn2	Ikzf1^{tm1.1(Pax5)Mbu}/Ikzf1⁺ Tcf3^tm1Mbu/Tcf3^tm1Mbu Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺	involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca	MGI:3804204

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:118111 )

• mice die between 2 and 4 months of age

hematopoietic system

enlarged thymus ( J:118111 )

thymus hypoplasia ( J:118111 )

• significantly reduced at 2 weeks relative to Igh^tm1(PAX5)Mbu homozygotes

enlarged spleen ( J:118111 )

abnormal erythropoiesis ( J:80815 )

• number of erythroid precursors in bone marrow decreases to 1/20 of control numbers by 8 weeks of age

abnormal B cell differentiation ( J:80815 )

increased pro-B cell number ( J:80815 )

• at 8 weeks, number of pro-B cells is still 3.5-fold greater than controls

decreased double-positive T cell number ( J:118111 )

• significantly reduced at 2 weeks relative to Igh^tm1(PAX5)Mbu homozygotes

increased B cell number ( J:80815 )

• at E18.5, there are ~7-fold more B lymphocytes than in controls

immune system

enlarged thymus ( J:118111 )

thymus hypoplasia ( J:118111 )

• significantly reduced at 2 weeks relative to Igh^tm1(PAX5)Mbu homozygotes

enlarged spleen ( J:118111 )

abnormal B cell differentiation ( J:80815 )

increased pro-B cell number ( J:80815 )

• at 8 weeks, number of pro-B cells is still 3.5-fold greater than controls

decreased double-positive T cell number ( J:118111 )

• significantly reduced at 2 weeks relative to Igh^tm1(PAX5)Mbu homozygotes

increased B cell number ( J:80815 )

• at E18.5, there are ~7-fold more B lymphocytes than in controls

enlarged lymph nodes ( J:118111 )

neoplasm

increased lymphoma incidence ( J:118111 )

• lymphoid organs show diffuse infiltration by diffuse lymphoblastic lymphoma

• extensive tumor infiltrates are found in other organs including heart, kidneys, lungs, liver, intestine and testis

increased T cell derived lymphoma incidence ( J:118111 )

endocrine/exocrine glands

enlarged thymus ( J:118111 )

thymus hypoplasia ( J:118111 )

• significantly reduced at 2 weeks relative to Igh^tm1(PAX5)Mbu homozygotes

increased T cell derived lymphoma incidence ( J:118111 )

growth/size/body

enlarged spleen ( J:118111 )

Allelic Composition	Ikzf1^{tm1.1(Pax5)Mbu}/Ikzf1⁺ Tcf3^tm1Mbu/Tcf3^tm1Mbu Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10^{Tg(Vav1-icre)A2Kio} mutation (3 available); any Commd10 mutation (24 available)
Ikzf1^{tm1.1(Pax5)Mbu} mutation (0 available); any Ikzf1 mutation (30 available)
Tcf3^tm1Mbu mutation (1 available); any Tcf3 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:137719 )

N	• development of pro-B cells is rescued

abnormal immunoglobulin heavy chain V(D)J recombination ( J:137719 )

• proximal VH7183-DJH and distal VHJ558-DJH rearrangements of the IgH are reduced compared to in wild-type mice

• Vk-Jk recombination of the Igk locus is absent

hematopoietic system

abnormal immunoglobulin heavy chain V(D)J recombination ( J:137719 )

• proximal VH7183-DJH and distal VHJ558-DJH rearrangements of the IgH are reduced compared to in wild-type mice

• Vk-Jk recombination of the Igk locus is absent

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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