|
Allele Symbol Allele Name Allele ID |
Tbx6tm1Pa targeted mutation 1, Virginia Papaioannou MGI:2447721 |
||||||||||||||||||||
| Summary |
4 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• abnormal patterning at E8.5
|
|
• ectopic neural tube development at E9.5
|
|
• ectopic neural tube development at E9.5
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• by E12.5 all mutant embryos were dead, presumably due to hemorrhaging of embryonic blood vessels
|
|
• multiple hematomas in the spinal cord and tail buds at E8.5
• extraembryonic vasculature appeared normal
|
|
• lack of segmental arteries
|
|
• severe defects in the differentiation of paraxial mesoderm
|
|
• seen at E8.5
|
|
• absence of trunk somites at E8.5
• irregular somites form in the neck region
• posterior paraxial tissue does not form somites, but forms neural tube like structures that flank the axial neural tube
|
|
• seen at E8.5
• tail buds examined at E9.5 and E10.5 contained undifferentiated mesenchymal cells and multiple rosettes of epithelializing tissue lateral to the neural tube
|
|
• seen at E8.5
|
|
• seen at E8.5
• tail buds examined at E9.5 and E10.5 contained undifferentiated mesenchymal cells and multiple rosettes of epithelializing tissue lateral to the neural tube
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• some cilia are shorter and thicker
• most cilia have terminal bulges or balloon like structures
|
|
• direction of turning is completely reversed in 18% (7 of 38) of embryos and partially reversed in an additional 4 embryos
• embryos with reversal of turning direction do not always also have reversal of the direction of heart looping
|
|
• at E9.5 - E10.5, about 40% of embryos show either completely reversed or ventral rather than horizontal looping
|
|
• some cilia are shorter and thicker
• most cilia have terminal bulges or balloon like structures
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• absence of genes associated with neural tube development in the paraxial compartment concomitant with absence of tubular structures at E9.5
• expression analysis indicates absence of markers for the paraxial mesoderm, intermediate mesoderm and endoderm
• however, unlike mice homozygous for the Tbx6 mutation alone, no ectopic expression of Sox2 is seen in the neural tube
|
|
• absence of genes associated with neural tube development in the paraxial compartment concomitant with absence of tubular structures at E9.5
• expression analysis indicates absence of markers for the paraxial mesoderm, intermediate mesoderm and endoderm
• however, unlike mice homozygous for the Tbx6 mutation alone, no ectopic expression of Sox2 is seen in the neural tube
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/23/2024 MGI 6.23 |
|
|
|
||
Analysis Tools