All Phenotypes Mbd4<tm1Wed> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mbd4^tm1Wed
targeted mutation 1, Winfried Edelmann
MGI:2447611

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mbd4^tm1Wed/Mbd4^tm1Wed	B6.Cg-Mbd4^tm1Wed/J	MGI:5292473
hm2	Mbd4^tm1Wed/Mbd4^tm1Wed	involves: 129/Sv * C57BL/6 * SJL	MGI:3719439
cx3	Apc^tm1Rak/Apc⁺ Mbd4^tm1Wed/Mbd4^tm1Wed	involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * SJL	MGI:3719440

Allelic Composition	Mbd4^tm1Wed/Mbd4^tm1Wed
Genetic Background	B6.Cg-Mbd4^tm1Wed/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mbd4^tm1Wed mutation (1 available); any Mbd4 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal DNA methylation ( J:175891 )

• at E8.33, demethylation of the Hes5 promoter is impaired

Allelic Composition	Mbd4^tm1Wed/Mbd4^tm1Wed
Genetic Background	involves: 129/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mbd4^tm1Wed mutation (1 available); any Mbd4 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell physiology ( J:80319 )

• the occurrence of transition mutations in splenocytes is increased 3-fold and more than 2-fold in small intestinal epithelial cells

• CG to TA transitions occur more than twice as often compared to in wild-type mice

Allelic Composition	Apc^tm1Rak/Apc⁺ Mbd4^tm1Wed/Mbd4^tm1Wed
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Rak mutation (0 available); any Apc mutation (151 available)
Mbd4^tm1Wed mutation (1 available); any Mbd4 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Microadenoma in Mbd4^tm1Wed/Mbd4^tm1Wed Apc^tm1Rak/Apc⁺ gastrointestinal tract

neoplasm

increased gastrointestinal tumor incidence ( J:80319 )

• the multiplicity of gastro-intestinal tumors is increased 2.4 times relative to Apc^tm1Rak heterozygotes

• mice have greater number of tumors in the jejunum and ileum than in Apc^tm1Rak heterozygotes

• mice have 10-fold increase in microadenomas compared to Apc^tm1Rak heterozygotes

• tumor progression is accelerated relative to Apc^tm1Rak heterozygotes

cellular

abnormal cell physiology ( J:80319 )

• mice tumors have more CG to TA transition mutations in the Apc gene than in Apc^tm1Rak heterozygotes

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:80319 )

• the multiplicity of gastro-intestinal tumors is increased 2.4 times relative to Apc^tm1Rak heterozygotes

• mice have greater number of tumors in the jejunum and ileum than in Apc^tm1Rak heterozygotes

• mice have 10-fold increase in microadenomas compared to Apc^tm1Rak heterozygotes

• tumor progression is accelerated relative to Apc^tm1Rak heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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