All Phenotypes Tg(PDGFB-PSEN1)1Jhd MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(PDGFB-PSEN1)1Jhd
transgene insertion 1, John Hardy
MGI:2447324

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	App^tm1Ck/App^tm1Ck Tg(PDGFB-PSEN1)1Jhd/0	involves: 129 * Black Swiss * C57BL/6 * DBA/2 * SW	MGI:5581665

Allelic Composition	App^tm1Ck/App^tm1Ck Tg(PDGFB-PSEN1)1Jhd/0
Genetic Background	involves: 129 * Black Swiss * C57BL/6 * DBA/2 * SW

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
App^tm1Ck mutation (0 available); any App mutation (89 available)
Tg(PDGFB-PSEN1)1Jhd mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cholinergic neuron morphology ( J:102542 )

• areas of higher density of cholinergic fibers in the cortex at 20 months of age

• however, mice do not form amyloid beta plaques

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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