Phenotypes associated with this allele

• Allele Symbol: Igh^tm1Cog
• Allele Name: targeted mutation 1, Michel Cogne
• Allele ID: MGI:2447194
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh^tm1Cog/Igh^tm1Cog	involves: 129S2/SvPas * C57BL/6	MGI:3815491

Genotype
MGI:3815491

hm1

• Allelic Composition: Igh^tm1Cog/Igh^tm1Cog
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal immunoglobulin heavy chain V(D)J recombination ( J:80654 )

• there are no detectable rearranged heavy chain V-D-J transcripts, either as mature transcripts spliced onto C-mu or as primary transcripts still including the JH-C-mu intron

• genomic analysis does reveal that variable and diversity gene segments undergo recombination with the first three, but not the fourth, joining segments

• some differing biases occur with the D segments including a strong bias to using DQ52

arrested B cell differentiation ( J:80654 )

• B cell differentiation appears to be arrested at the pro-B cell stage

• there is an expanded B220⁺, c-Kit⁺ CD43⁺ CD25^- sIgM^- pro-B cell population and an absent B220⁺, CD43^- CD25⁺ pre-B cell population in the bone marrow

absent B cells ( J:80654 )

• B cells are absent from the bone marrow, spleen, and from circulation

decreased immunoglobulin level ( J:80654 )

decreased IgA level ( J:80654 )

• IgA is absent from circulation

decreased IgE level ( J:80654 )

• IgE is absent form circulation

decreased IgG1 level ( J:80654 )

• mice born to homozygote mothers lack circulating IgG1 antibodies

• mice born to heterozygote mothers have some IgG detectable due to persistence of maternal antibodies

decreased IgG2a level ( J:80654 )

• mice born to homozygote mothers lack circulating IgG2a antibodies

• mice born to heterozygote mothers have some IgG detectable due to persistence of maternal antibodies

decreased IgG2b level ( J:80654 )

• mice born to homozygote mothers lack circulating IgG2b antibodies

• mice born to heterozygote mothers have some IgG detectable due to persistence of maternal antibodies

decreased IgG3 level ( J:80654 )

• mice born to homozygote mothers lack circulating IgG3 antibodies

• mice born to heterozygote mothers have some IgG detectable due to persistence of maternal antibodies

decreased IgM level ( J:80654 )

• IgM is absent from circulation

hematopoietic system

abnormal immunoglobulin heavy chain V(D)J recombination ( J:80654 )

• there are no detectable rearranged heavy chain V-D-J transcripts, either as mature transcripts spliced onto C-mu or as primary transcripts still including the JH-C-mu intron

• genomic analysis does reveal that variable and diversity gene segments undergo recombination with the first three, but not the fourth, joining segments

• some differing biases occur with the D segments including a strong bias to using DQ52

arrested B cell differentiation ( J:80654 )

• B cell differentiation appears to be arrested at the pro-B cell stage

• there is an expanded B220⁺, c-Kit⁺ CD43⁺ CD25^- sIgM^- pro-B cell population and an absent B220⁺, CD43^- CD25⁺ pre-B cell population in the bone marrow

absent B cells ( J:80654 )

• B cells are absent from the bone marrow, spleen, and from circulation

decreased immunoglobulin level ( J:80654 )

decreased IgA level ( J:80654 )

• IgA is absent from circulation

decreased IgE level ( J:80654 )

• IgE is absent form circulation

decreased IgG1 level ( J:80654 )

• mice born to homozygote mothers lack circulating IgG1 antibodies

• mice born to heterozygote mothers have some IgG detectable due to persistence of maternal antibodies

decreased IgG2a level ( J:80654 )

• mice born to homozygote mothers lack circulating IgG2a antibodies

• mice born to heterozygote mothers have some IgG detectable due to persistence of maternal antibodies

decreased IgG2b level ( J:80654 )

• mice born to homozygote mothers lack circulating IgG2b antibodies

• mice born to heterozygote mothers have some IgG detectable due to persistence of maternal antibodies

decreased IgG3 level ( J:80654 )

• mice born to homozygote mothers lack circulating IgG3 antibodies

• mice born to heterozygote mothers have some IgG detectable due to persistence of maternal antibodies

decreased IgM level ( J:80654 )

• IgM is absent from circulation