Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prnp-ITM2B*)6Jckr mutation
(0 available)
Tg(Thy1-APP)3Somm mutation
(1 available)
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nervous system
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• at 13 months, mice exhibit a 70% reduction in neocortical amyloid beta deposition compared with Tg(Thy1-APP)3Somm mice
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lamp5em1Lmit mutation
(0 available);
any
Lamp5 mutation
(28 available)
Tg(Thy1-APP)3Somm mutation
(1 available)
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mortality/aging
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• mice exhibit earlier and more rapid mortality and poor overall survival compared to single Tg(Thy1-APP)3Somm hemizygotes
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behavior/neurological
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• mice show increased hyperactivity over the entire test period compared to single Tg(Thy1-APP)3Somm hemizygotes
• memory could not be tested due to high premature mortality rate
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nervous system
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• hippocampal EEG recordings show a further increase in spontaneous discharges and spike trains than seen in single Tg(Thy1-APP)3Somm hemizygotes
• spectral power at gamma (30-100 Hz) frequency is increased more than in single Tg(Thy1-APP)3Somm hemizygotes or Lamp5em1Lmit/Lamp5+ Tg(Thy1-APP)3Somm/0 mice, indicating neuronal network hypersynchronicity
• theta/gamma cross frequency coupling, an EEG measure linked to memory, is disrupted more than in single Tg(Thy1-APP)3Somm hemizygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-APP)3Somm mutation
(1 available)
Tnfrsf1atm1Imx mutation
(6 available);
any
Tnfrsf1a mutation
(47 available)
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nervous system
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N |
• at 24 months, mice exhibit little neuronal loss unlike Tg(Thy1-APP)3Somm mice
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• mice exhibit less microglial activation compared with Tg(Thy1-APP)3Somm mice
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• at 24 months, mice exhibit reduced amyloid plaques compared with Tg(Thy1-APP)3Somm mice
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• mice exhibit reduced cerebral amyloid angiopathy compared with Tg(Thy1-APP)3Somm mice
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behavior/neurological
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N |
• mice exhibit normal exploratory learning and memory retention unlike Tg(Thy1-APP)3Somm mice
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hematopoietic system
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• mice exhibit less microglial activation compared with Tg(Thy1-APP)3Somm mice
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immune system
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• mice exhibit less microglial activation compared with Tg(Thy1-APP)3Somm mice
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lamp5em1Lmit mutation
(0 available);
any
Lamp5 mutation
(28 available)
Tg(Thy1-APP)3Somm mutation
(1 available)
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mortality/aging
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• survival is reduced similarly to that seen in single Tg(Thy1-APP)3Somm hemizygotes until 150 days and thereafter shows a trend towards increased mortality
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behavior/neurological
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• learning in the Morris water maze is impaired compared to single Tg(Thy1-APP)3Somm hemizygotes at 12 months of age
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• memory formation in the Morris water maze is impaired compared to single Tg(Thy1-APP)3Somm hemizygotes at 12 months of age
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homeostasis/metabolism
nervous system
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• amyloid beta formation and plaque load in aged mice is similar to single Tg(Thy1-APP)3Somm hemizygotes
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• spectral power at gamma (30-100 Hz) frequency is increased more than in single Tg(Thy1-APP)3Somm hemizygotes, indicating neuronal network hypersynchronicity
• theta/gamma cross frequency coupling, an EEG measure linked to memory, is disrupted more than in single Tg(Thy1-APP)3Somm hemizygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Jdm mutation
(1 available);
any
Abca1 mutation
(88 available)
Tg(Thy1-APP)3Somm mutation
(1 available)
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mortality/aging
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• fewer than expected mice are present at weaning
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nervous system
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• mice exhibit more cerebral amyloid angiopathy-associated cerebral hemorrhage than Tg(Thy1-APP)3Somm mice
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• at 13 months, mice exhibit more cerebral amyloid angiopathy than in Tg(Thy1-APP)3Somm mice
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cardiovascular system
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• mice exhibit more cerebral amyloid angiopathy-associated cerebral hemorrhage than Tg(Thy1-APP)3Somm mice
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-APP)3Somm mutation
(1 available)
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nervous system
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• amyloid plaques are associated with alterations in axonal growth and ectopic synaptic differentiation
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• vascular amyloid is associated with ectopic entorhinal boutons
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• axons that line the periphery of beta-amyloid plaques exhibit swelling unlike in wild-type mice
• entorhinal fibers extend outside the termination zone unlike in wild-type mice
• commissure axons extend into the outer molecular layer unlike in wild-type mice
• amyloid plaques are associated with alterations in axonal growth and ectopic synaptic differentiation
• vascular amyloid is associated with ectopic entorhinal boutons
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behavior/neurological
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• at 6 months during the first 2 hours
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• impaired acquisition in the Morris water maze; the number of quadrant entries and the escape latencies are higher than in controls
• however, mutants are unaffected in open-field, elevated plus-maze, emergence tests, tests measuring motor coordination, during the probe trial and while swimming towards a visible platform
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• in an isolation-induced/resident-intruder paradigm, mice exhibit a 4.6- and 59-fold increase in aggression at 6 and 12 months, respectively, compared with wild-type mice
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• 67% of animals exhibit myoclonic jumping behavior in home cage
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• reduced number of horizontal and vertical movements in the photocell monitor
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• at 3 months, mice exhibit lower light ambulation compared with wild-type mice
• at 6 months, mice exhibit increased in the ratio of dark to light ambulation during the second half of the active phase compared with wild-type mice
• at 12 months, circadian locomotor patterns are more constant than in wild-type mice
• at 12 months, mice exhibit increased dark and total ambulation compared with wild-type mice
• at 12 months, dark ambulation level is bimodal unlike in wild-type mice
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growth/size/body
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• 29% weight reduction compared to wild-type
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homeostasis/metabolism
Allelic
Composition |
Tg(Thy1-APP)3Somm/0
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Genetic
Background |
involves: C57BL/6 * C57BL/6J * DBA/2 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-APP)3Somm mutation
(1 available)
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mortality/aging
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• male, and more so, female mice show reduced survival
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behavior/neurological
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• 2-month-old mice present with slower habituation in the open field test, before development of memory deficits
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• 2-month-old mice present with in the open field test, before development of memory deficits
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homeostasis/metabolism
nervous system
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• amyloid beta formation and plaque
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• hippocampal EEG recordings show increased spontaneous discharges and spike trains compared to controls
• spectral power analysis shows increased high frequency power compared to controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-APP)3Somm mutation
(1 available)
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nervous system
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• mice exhibit aneurysm-like vasodilation unlike in wild-type mice
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• mice exhibit blood vessel ruptures that range from microhemorrhages to large hematomas unlike wild-type mice
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• mice exhibit leakage in the blood-brain barrier unlike wild-type mice
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• develop amyloid beta deposits in the neocortex and hippocampus starting at 6 months of age, which increase in size and number with age
(J:44603)
• by 24 months of age, deposits occupy a substantial area of the neocortex and hippocampus and are found in the thalamus and olfactory nucleus and are isolated in the caudate putamen
(J:44603)
• develop almost exclusively congophilic plaques already at their first appearance
(J:44603)
• at 24 months
(J:134832)
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• in the neocortex, hippocampus, and thalamus and to a lesser degree in other regions such as septum, striatum, brainstem, and white matter
(J:67583)
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• mutants exhibit inflammatory responses in the brain, showing a massive glial response
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• loss of pyramidal neurons in the vicinity of amyloid beta deposits in the CA3 area
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• local distortion of the cholinergic fiber network is seen in the vicinity of plaques
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• local loss of neurons in the vicinity of plaques
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immune system
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• mutants exhibit inflammatory responses in the brain, showing a massive glial response
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cardiovascular system
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• mice exhibit aneurysm-like vasodilation unlike in wild-type mice
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• mice exhibit smooth muscle cell degeneration in amyloid laden blood vessels unlike wild-type mice
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• bicuculline-treated mice exhibit delayed and reduced amplitude of changes in cerebral blood volume compared with similarly treated wild-type mice
• at 25 months, acetazolamide-treated mice exhibit a smaller increase in the percent change of cerebral blood volume compared with similarly treated wild-type mice
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• mice exhibit blood vessel ruptures that range from microhemorrhages to large hematomas unlike wild-type mice
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• mice exhibit leakage in the blood-brain barrier unlike wild-type mice
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• mice exhibit cerebral amyloid angiopathy associated vasculitis unlike wild-type mice
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muscle
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• mice exhibit smooth muscle cell degeneration in amyloid laden blood vessels unlike wild-type mice
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homeostasis/metabolism
behavior/neurological
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• at 6 months, mice exhibit reduced exploratory learning compared with wild-type mice
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• object recognition is impaired compared to in wild-type mice
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hematopoietic system
Analysis Tools