Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkcetm1Msg mutation
(1 available);
any
Prkce mutation
(39 available)
Tg(Prnp-tTA)F959Sbp mutation
(1 available)
Tg(tetO-Prkce)T9Msg mutation
(0 available)
|
|
|
behavior/neurological
|
|
• in mice administered doxycycline for 2 weeks, restoration of wild-type drinking behavior
|
|
|
• increased duration of regaining ethanol-induced loss or righting response, increase in duration of pentobarbital-induced loss or righting response
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Cwe mutation
(39 available);
any
Prnp mutation
(150 available)
Tg(Prnp-tTA)F959Sbp mutation
(1 available)
Tg(tetO-ATXN3)2904Olri mutation
(0 available)
|
|
|
nervous system
|
|
• in some neuronal cells of the cerebral cortex by 20 month old mice
|
behavior/neurological
|
N |
• mice exhibit a normal gait and performance on a rotarod
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Cwe mutation
(39 available);
any
Prnp mutation
(150 available)
Tg(Prnp-tTA)F959Sbp mutation
(1 available)
Tg(tetO-ATXN3)2904Olri mutation
(0 available)
|
|
|
behavior/neurological
|
|
• mice spend more time in the inner regions of an open field compared with wild-type mice
|
|
|
• some mice exhibit spastic head movements unlike wild-type mice
|
|
|
• beginning at 2 to 3 months of age
|
|
|
• when lowered onto a horizontal pen, mice fail to walk along it and fall with severely affected mice unable to sit on the pen unlike wild-type mice
• mice exhibit impaired performance on a rotarod compared with mice containing only one of the transgenes
• however, mice treated with doxycycline exhibit improved rotarod performance
|
|
|
• in an open field test, especially in inner areas
|
nervous system
|
|
• in some neuronal cells of the cerebral cortex by 1 month old mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Cwe mutation
(39 available);
any
Prnp mutation
(150 available)
Tg(Prnp-tTA)F959Sbp mutation
(1 available)
Tg(tetO-ATXN3)2904Olri mutation
(0 available)
|
|
|
behavior/neurological
|
|
• mice spend more time in the inner regions of an open field than wild-type mice
|
|
|
• some mice exhibit spastic head movements unlike wild-type mice
|
|
|
• beginning at 2 to 3 months of age
|
|
|
• when lowered onto a horizontal pen, mice fail to walk along it and fall with severely affected mice unable to sit on the pen unlike wild-type mice
• mice exhibit impaired performance on a rotarod compared with mice containing only one of the transgenes
• however, mice treated with doxycycline exhibit improved rotarod performance
|
|
|
• at 20 months, mice exhibit an altered gait with smaller distance between steps compared with wild-type mice
|
nervous system
|
|
• in some neuronal cells of the cerebral cortex by 1 month old mice
|
growth/size/body
|
|
• mice exhibit reduced body weight compared with Tg(tetO-ATXN3)2904Olri mice
• however, treatment with doxycycline at 9 weeks of age restores weight
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Cwe mutation
(39 available);
any
Prnp mutation
(150 available)
Tg(Prnp-tTA)F959Sbp mutation
(1 available)
Tg(tetO-ATXN3)2904Olri mutation
(0 available)
|
|
|
behavior/neurological
|
|
• mice exhibit reduced motor learning on a rotarod compared with mice containing only one of the transgenes
|
|
|
• mice spend more time in the inner regions of an open field compared with wild-type mice
|
|
|
• some mice exhibit spastic head movements unlike wild-type mice
|
|
|
• beginning at 2 to 3 months of age
|
|
|
• when lowered onto a horizontal pen, mice fail to walk along it and fall with severely affected mice unable to sit on the pen unlike wild-type mice
• as early as 9 weeks of age, mice exhibit impaired performance on a rotarod compared with mice containing only one of the transgenes
• however, mice treated with doxycycline for 5 months exhibit improved rotarod performance
|
nervous system
|
|
• at 21 months, Purkinje cells are smaller than in wild-type mice
• however, mice treated with doxycycline treatment from 2 months of age exhibit normal Purkinje cell size
|
|
|
• at 21 months, the cerebellar molecular layer is thinner than in wild-type mice
• however, mice treated with doxycycline treatment from 2 months of age exhibit normal cerebellar molecular layer thickness
|
growth/size/body
|
|
• mice exhibit reduced body weight compared with Tg(tetO-ATXN3)2904Olri mice
• however, treatment with doxycycline at 9 weeks of age restores weight
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prnp-tTA)F959Sbp mutation
(1 available)
Tg(TetO-Nfkbia*S32A*S36A)1Wcg mutation
(0 available)
|
|
|
behavior/neurological
|
|
• increased exploratory behavior observed in open and closed arms of plus maze and open field test
|
|
|
• mice exhibit an enhanced spatial learning by locating the visible and hidden platforms of the Morris water maze in less time than controls
|
|
|
• mice exhibit an accelerated retrieval of spatial memory by remaining in target quadrant of probe trial (platform removed from water maze)
|
|
|
• mice are more active than controls
|
|
|
• increased number of rearing events in the open field test
|
|
|
• mice exhibit increased sensitivity to handling-induced seizures
|
nervous system
|
|
• mice exhibit increased sensitivity to handling-induced seizures
|
|
|
• I/O function, a measure of synaptic strength, in untrained mice is significantly impaired relative to controls
|
|
|
• LTP induced in hippocampal slices is higher than controls, however synapse numbers are not increased
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prnp-tTA)F959Sbp mutation
(1 available)
Tg(tetO-Chrnb2*V287L)H3Gica mutation
(1 available)
|
|
|
nervous system
|
|
• mice exhibit seizures of 3 to 21 episodes during 24 hours each lasting 15 to 40 seconds
• seizures occur mainly during periods of increased delta activity regardless of doxycycline treatment as adults to silence the transgene
• most seizures occur during the light period (resting-sleeping)
• however, doxycycline treatment between E1 and P15 prevents seizures
|
|
|
• mice display abnormal electroencephalogram with frequent spikes of high amplitudes unlike wild-type mice
• delta waves predominant unlike in wild-type mice where theta waves are more representatives
• seizures occur mainly during periods of increased delta activity regardless of doxycycline treatment as adults to silence the transgene
• however, doxycycline treatment between E1 and P15 prevents high amplitude spikes and restores prevalence of theta waves
|
behavior/neurological
|
|
• mice exhibit seizures of 3 to 21 episodes during 24 hours each lasting 15 to 40 seconds
• seizures occur mainly during periods of increased delta activity regardless of doxycycline treatment as adults to silence the transgene
• most seizures occur during the light period (resting-sleeping)
• however, doxycycline treatment between E1 and P15 prevents seizures
|
Analysis Tools