Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rargtm4Ipc mutation
(0 available);
any
Rarg mutation
(151 available)
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growth/size/body
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• by 3 weeks of age, mutants are on average 10% smaller than wild-type, with a few more than 25% smaller
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respiratory system
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• ventral extension of the cricoid cartilage in 16 of 24 mutants
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skeleton
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• ventral extension of the cricoid cartilage in 16 of 24 mutants
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• 12% of mutants show defects in cervical vertebrae consisting of malformations of C2 (bifidus, dyssymphysis, enlarged neural arch, fusion with C3) and partial agenesis of the body of C4 and C7 to C6 transformation
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Allelic Composition |
Rargtm4Ipc/Rarg+
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Genetic Background |
involves: 129 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rargtm4Ipc mutation
(0 available);
any
Rarg mutation
(151 available)
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respiratory system
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• ventral extension of the cricoid cartilage is present in 2 of 11 heterozygotes
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skeleton
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• ventral extension of the cricoid cartilage is present in 2 of 11 heterozygotes
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rargtm4Ipc mutation
(0 available);
any
Rarg mutation
(151 available)
Rxratm2Ipc mutation
(0 available);
any
Rxra mutation
(30 available)
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vision/eye
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• increase in the severity of the anterior eye segment malformations seen in single Rxratm2Ipc homozygotes
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rarbtm1Mma mutation
(0 available);
any
Rarb mutation
(39 available)
Rargtm4Ipc mutation
(0 available);
any
Rarg mutation
(151 available)
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renal/urinary system
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• 3 of 4 unilaterally lack a kidney
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Raratm1Ipc mutation
(0 available);
any
Rara mutation
(79 available)
Rargtm4Ipc mutation
(0 available);
any
Rarg mutation
(151 available)
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mortality/aging
renal/urinary system
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• 5 of 6 show bilateral kidney hypoplasia
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• 1 of 6 shows kidney agenesis
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skeleton
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• double mutants exhibit an increase in the frequency and severity of axial skeletal malformations compared to the single mutants
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• penetrance of a unilateral pterygoquadrate element (a cartilaginous or osseous extension fusing the incus to the alisphenoid bone) is similar to that seen in single homozygous Rara mutants (3 of 16 mutants)
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• 6 of 10 show bilateral agenesis of the zygomatic process of the squamosal bone
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• low penetrance of fusion between the greater horns of thyroid cartilage and the hyoid bone (1 of 6)
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• penetrance of a unilateral pterygoquadrate element (a cartilaginous or osseous extension fusing the incus to the alisphenoid bone) is similar to that seen in single homozygous Rara mutants (3 of 16 mutants)
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• the ventral extension of the cricoid cartilage is markedly longer in the double mutant than in either single mutant
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• low penetrance of fusion between the greater horns of thyroid cartilage and the hyoid bone (1 of 6)
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• 100% penetrance of cervical vertebrae defects
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• 7 of 9 show C2-C3 fusion
• 5 of 9 show C1-C2 fusion
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cardiovascular system
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• low penetrance (1 of 6 mutants)
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• low penetrance (1 of 6 mutants)
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craniofacial
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• penetrance of a unilateral pterygoquadrate element (a cartilaginous or osseous extension fusing the incus to the alisphenoid bone) is similar to that seen in single homozygous Rara mutants (3 of 16 mutants)
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• 6 of 10 show bilateral agenesis of the zygomatic process of the squamosal bone
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• low penetrance of fusion between the greater horns of thyroid cartilage and the hyoid bone (1 of 6)
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• penetrance of a unilateral pterygoquadrate element (a cartilaginous or osseous extension fusing the incus to the alisphenoid bone) is similar to that seen in single homozygous Rara mutants (3 of 16 mutants)
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hearing/vestibular/ear
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• penetrance of a unilateral pterygoquadrate element (a cartilaginous or osseous extension fusing the incus to the alisphenoid bone) is similar to that seen in single homozygous Rara mutants (3 of 16 mutants)
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respiratory system
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• the ventral extension of the cricoid cartilage is markedly longer in the double mutant than in either single mutant
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• low penetrance of fusion between the greater horns of thyroid cartilage and the hyoid bone (1 of 6)
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