Phenotypes associated with this allele

• Allele Symbol: Xbp1^tm1Nogu
• Allele Name: targeted mutation 1, Shigeru Noguchi
• Allele ID: MGI:2445686
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Xbp1^tm1Nogu/Xbp1^tm1Nogu	involves: 129S/SvEv * A/J	MGI:2678536

Genotype
MGI:2678536

hm1

• Allelic Composition: Xbp1^tm1Nogu/Xbp1^tm1Nogu
• Genetic Background: involves: 129S/SvEv * A/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:56678 )

• homozygotes die between E9.5 and E14.5, with ~50% found dead at E10.5

cardiovascular system

absent trabeculae carneae ( J:56678 )

• at E10.5-E12.5, homozygotes with myocardial necrosis display reduced ventricular trabeculation

myocardium necrosis ( J:56678 )

• at E10.5-E12.5, homozygotes exhibit cardiomyocyte necrosis in the atrium and the truncus arteriosus with its following ventricle, with notable eosinophilic debris and cells displaying karyopycnosis and karyorrhexis

• no necrotic alteration is detected in the endocardial cushion or conotruncal ridge

abnormal heart development ( J:56678 )

thin ventricular wall ( J:56678 )

• at E10.5-E12.5, homozygotes with myocardial necrosis display a thin ventricular wall

enlarged pericardium ( J:56678 )

growth/size/body

embryonic growth retardation ( J:56678 )

• at E9.5, homozygotes appear morphologically normal; however, some mutants appear to be growth-retarded by E10.5 and start undergoing resorption

homeostasis/metabolism

anoxia ( J:56678 )

• homozygotes die by anoxia as a result of cardiac dysfunction

muscle

absent trabeculae carneae ( J:56678 )

• at E10.5-E12.5, homozygotes with myocardial necrosis display reduced ventricular trabeculation

myocardium necrosis ( J:56678 )

• at E10.5-E12.5, homozygotes exhibit cardiomyocyte necrosis in the atrium and the truncus arteriosus with its following ventricle, with notable eosinophilic debris and cells displaying karyopycnosis and karyorrhexis

• no necrotic alteration is detected in the endocardial cushion or conotruncal ridge

nervous system

wavy neural tube ( J:56678 )

• at E10.5-E11.5, some homozygotes display waviness of the neuroepithelium; these mutants die within 24 hrs (i.e. by E12.5)

embryo

embryo tissue necrosis ( J:56678 )

• dead embryos display coagulation necrosis in all tissues except for the heart

embryonic growth retardation ( J:56678 )

• at E9.5, homozygotes appear morphologically normal; however, some mutants appear to be growth-retarded by E10.5 and start undergoing resorption

wavy neural tube ( J:56678 )

• at E10.5-E11.5, some homozygotes display waviness of the neuroepithelium; these mutants die within 24 hrs (i.e. by E12.5)

cellular

myocardium necrosis ( J:56678 )

• at E10.5-E12.5, homozygotes exhibit cardiomyocyte necrosis in the atrium and the truncus arteriosus with its following ventricle, with notable eosinophilic debris and cells displaying karyopycnosis and karyorrhexis

• no necrotic alteration is detected in the endocardial cushion or conotruncal ridge

embryo tissue necrosis ( J:56678 )

• dead embryos display coagulation necrosis in all tissues except for the heart