Xbp1^tm1Nogu
Targeted Allele Detail

Summary

• Symbol: Xbp1^tm1Nogu
• Name: X-box binding protein 1; targeted mutation 1, Shigeru Noguchi
• MGI ID: MGI:2445686
• Gene: Xbp1 Location: Chr11:5470659-5475893 bp, + strand Genetic Position: Chr11, 3.61 cM
• Alliance: Xbp1^tm1Nogu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56678
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2 was disrupted by the insertion of a neomycin selection cassette such that translation would produce a protein containing 80 amino terminal residues as well as 5 residues derived from linker sequence. RT-PCR indicated that normal transcript was absent in homozygous mutant embryos. (J:56678)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xbp1 Mutation: 28 strains or lines available

References

• Original: J:56678 Masaki T, et al., Targeted disruption of CRE-binding factor TREB5 gene leads to cellular necrosis in cardiac myocytes at the embryonic stage. Biochem Biophys Res Commun. 1999 Aug 2;261(2):350-6
• All: 1 reference(s)