All Phenotypes Tg(Mpz-cre)1Brn MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nf2^tm2Gth/Nf2^tm2Gth Tg(Mpz-cre)1Brn/0	involves: 129P2/OlaHsd * FVB/N	MGI:3850388
cn2	Nf2^tm1Gth/Nf2^tm2Gth Tg(Mpz-cre)1Brn/0	involves: 129P2/OlaHsd * FVB/N	MGI:3850393
cn3	Nf1^tm1Par/Nf1^tm1Tyj Tg(Mpz-cre)1Brn/0	involves: 129/Sv * FVB/N	MGI:3776064
cn4	Erbb2^tm1Klee/Erbb2^tm1Klee Tg(Mpz-cre)1Brn/0	involves: FVB/N	MGI:3845119

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:63264 )

premature death ( J:63264 )

• mice have a short lifespan dying by 10 months of age

postnatal lethality, incomplete penetrance ( J:63264 )

• fewer mice than expected are obtained (no time point for lethality given)

• however, postnatal lethality can be partially rescued by supplementing food with porridge

reproductive system

infertility ( J:63264 )

neoplasm

increased tumor incidence ( J:63264 )

• after 10 months, mice develop benign and malignant Schwann cell tumors

craniofacial

delayed tooth eruption ( J:63264 )

• at P17 and P19, molar eruption is retarded or absent

failure of tooth eruption ( J:63264 )

• at P17 and P19, molar eruption is retarded or absent

nervous system

abnormal Schwann cell morphology ( J:63264 )

• 2 of 4 mice and 4 months and 1 mouse at P17 exhibit hyperplasia or hypertrophy in Schwann cells of distal peripheral nerves

• at P19 and P33, Schwann cells are without a clear relation with an axon and many of the myelin sheaths herniated and loop into the central axonal region unlike in wild-type mice

growth/size/body

delayed tooth eruption ( J:63264 )

• at P17 and P19, molar eruption is retarded or absent

failure of tooth eruption ( J:63264 )

• at P17 and P19, molar eruption is retarded or absent

decreased body size ( J:63264 )

decreased body weight ( J:63264 )

hearing/vestibular/ear

increased susceptibility to otitis media ( J:63264 )

immune system

increased susceptibility to otitis media ( J:63264 )

skeleton

delayed tooth eruption ( J:63264 )

• at P17 and P19, molar eruption is retarded or absent

failure of tooth eruption ( J:63264 )

• at P17 and P19, molar eruption is retarded or absent

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
otitis media		DOID:10754		J:63264

Allelic Composition	Nf2^tm1Gth/Nf2^tm2Gth Tg(Mpz-cre)1Brn/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2^tm1Gth mutation (1 available); any Nf2 mutation (65 available)
Nf2^tm2Gth mutation (3 available); any Nf2 mutation (65 available)
Tg(Mpz-cre)1Brn mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:63264 )

• the few mice that are produced die prior to weaning

nervous system

abnormal Schwann cell morphology ( J:63264 )

• at P17, one mouse exhibited a subcutaneous Schwann cell nodule

neoplasm

increased hamartoma incidence ( J:63264 )

• at P19, one mouse exhibited a hamartoma of the olfactory bulb composed of Schwann and neural cells

Allelic Composition	Nf1^tm1Par/Nf1^tm1Tyj Tg(Mpz-cre)1Brn/0
Genetic Background	involves: 129/Sv * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1^tm1Par mutation (4 available); any Nf1 mutation (157 available)
Nf1^tm1Tyj mutation (3 available); any Nf1 mutation (157 available)
Tg(Mpz-cre)1Brn mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:131914 )

N	• neural crest stem cells do not abnormally persist in the peripheral nervous system in adult mice

increased neurofibroma incidence ( J:131914 )

• at 15 - 20 months of age, all 6 mice examined had plexiform neurofibromas compared to 0 fibromas in control littermates

neoplasm

increased neurofibroma incidence ( J:131914 )

• at 15 - 20 months of age, all 6 mice examined had plexiform neurofibromas compared to 0 fibromas in control littermates

Allelic Composition	Erbb2^tm1Klee/Erbb2^tm1Klee Tg(Mpz-cre)1Brn/0
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^tm1Klee mutation (0 available); any Erbb2 mutation (59 available)
Tg(Mpz-cre)1Brn mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:81239 )

• mutants are indistinguishable from controls and do not show loss of enteric neurons

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