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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Rbp3-cre)1Brn
transgene insertion 1, Anton Berns
MGI:2445226
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rb1tm2Brn/Rb1tm2Brn
Trp53tm1Brd/Trp53+
Tg(Rbp3-cre)1Brn/0 		involves: 129 * 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:2653661
cn2
 		Rb1tm2Brn/Rb1tm2Brn
Tg(Rbp3-cre)1Brn/0 		involves: 129 * FVB/N MGI:2653660


Genotype
MGI:2653661
cn1
Allelic
Composition		 Rb1tm2Brn/Rb1tm2Brn
Trp53tm1Brd/Trp53+
Tg(Rbp3-cre)1Brn/0
Genetic
Background		 involves: 129 * 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm2Brn mutation (2 available); any Rb1 mutation (116 available)
Tg(Rbp3-cre)1Brn mutation (0 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (238 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
abnormal tumor morphology ( J:77982 )
• loss of heterozygosity of Trp53 in the neuroendocrine tumors
increased tumor incidence ( J:77982 )
• develop pituitary gland and pineal gland tumors
• pinealoblastomas locally invade the brain




Genotype
MGI:2653660
cn2
Allelic
Composition		 Rb1tm2Brn/Rb1tm2Brn
Tg(Rbp3-cre)1Brn/0
Genetic
Background		 involves: 129 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm2Brn mutation (2 available); any Rb1 mutation (116 available)
Tg(Rbp3-cre)1Brn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased pituitary adenohypophysis tumor incidence ( J:77982 )
• develop pituitary gland tumors that arise from the anterior lobe of the pituitary gland
• however, do not develop retinoblastomas or pineal gland tumors
increased pituitary melanotroph tumor incidence ( J:77982 )
• develop pituitary gland tumors that arise from the intermediate lobe of the pituitary gland

endocrine/exocrine glands
increased pituitary adenohypophysis tumor incidence ( J:77982 )
• develop pituitary gland tumors that arise from the anterior lobe of the pituitary gland
• however, do not develop retinoblastomas or pineal gland tumors
increased pituitary melanotroph tumor incidence ( J:77982 )
• develop pituitary gland tumors that arise from the intermediate lobe of the pituitary gland

vision/eye
vision/eye phenotype ( J:77982 )
N
• retinas appear normal

nervous system
increased pituitary adenohypophysis tumor incidence ( J:77982 )
• develop pituitary gland tumors that arise from the anterior lobe of the pituitary gland
• however, do not develop retinoblastomas or pineal gland tumors
increased pituitary melanotroph tumor incidence ( J:77982 )
• develop pituitary gland tumors that arise from the intermediate lobe of the pituitary gland




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory