All Phenotypes Glis1<tm1Mnks> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Glis1^tm1Mnks
targeted mutation 1, Misako Nakashima
MGI:2445222

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Glis1^tm1Mnks/Glis1^tm1Mnks	either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Swiss Webster)	MGI:3615801
cx2	Gli1^tm1Alj/Gli1^tm1Alj Glis1^tm1Mnks/Glis1^tm1Mnks	mixed	MGI:3615812
cx3	Gli3^Xt/Gli3^Xt Glis1^tm1Mnks/Glis1^tm1Mnks	mixed	MGI:3615815

Allelic Composition	Glis1^tm1Mnks/Glis1^tm1Mnks
Genetic Background	either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Swiss Webster)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glis1^tm1Mnks mutation (0 available); any Glis1 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:80052 )

• homozygous mice up to 6 months of age exhibit no obvious phenotype including behavioral, kidney and tooth defects

Allelic Composition	Gli1^tm1Alj/Gli1^tm1Alj Glis1^tm1Mnks/Glis1^tm1Mnks
Genetic Background	mixed

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1^tm1Alj mutation (0 available); any Gli1 mutation (48 available)
Glis1^tm1Mnks mutation (0 available); any Glis1 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:80052 )

• double homozygous mice survive to at least 3 months of age and appear normal

Allelic Composition	Gli3^Xt/Gli3^Xt Glis1^tm1Mnks/Glis1^tm1Mnks
Genetic Background	mixed

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt mutation (1 available); any Gli3 mutation (80 available)
Glis1^tm1Mnks mutation (0 available); any Glis1 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:80052 )

• similar to Gli3^xt homozygous mutant mice

nervous system

abnormal brain morphology ( J:80052 )

• embryonic dorsal brain defects are similar to Gli3^xt homozygous mutant embryos

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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