Analysis Tools
mortality/aging
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• all mice treated with a low dose of retinoic acid at E9 die perinatally unlike similarly treated wild-type mice
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skeleton
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• at P10, neural arches in the lumbar region remain open in 50% of mice unlike in wild-type mice
• however, the neural arches close by P14
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• sternum ossification centers in retinoic acid treated mice are shifted resulting in a crankshaft sternum unlike in similarly treated wild-type mice
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• deformed and wedge-shaped in the tail with fewer proliferating cells
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• 8 of 11 retinoic acid-treated mice lack the sixth vertebra unlike similarly treated wild-type mice
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• at P10, the vertebral growth plate in the tail is compressed and disrupted die to thinner zones of proliferating and hypertrophic cartilage compared to in wild-type mice
• fewer proliferating cells are present in the growth plate of tail vertebrae compared to in wild-type mice
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• at P10, neural arches lack processus spinosi unlike in wild-type mice
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• in the tail
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• 50% of retinoic acid treated mice exhibit a loss of ossification centers in cervical vertebrae unlike in similarly treated wild-type mice
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homeostasis/metabolism
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• all mice treated with a low dose of retinoic acid at E9 die perinatally unlike similarly treated wild-type mice
• 50% of retinoic acid treated mice exhibit a loss of ossification centers in cervical vertebrae unlike in similarly treated wild-type mice
• 8 of 11 retinoic acid-treated mice lack the sixth vertebra unlike similarly treated wild-type mice
• sternum ossification centers in retinoic acid treated mice are shifted resulting in a crankshaft sternum unlike in similarly treated wild-type mice
• retinoic acid treated mice have cleft palates resulting in breathing difficulties and premature death unlike similarly treated wild-type mice
• treatment with folic acid does not improve incidence of spina bifida occulta
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limbs/digits/tail
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• at P15, mice have several bends, but not kinks, in its tail unlike wild-type mice
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craniofacial
cleft palate
(
J:153789
)
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• in retinoic acid treated mice unlike similarly treated wild-type mice
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nervous system
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• at P10, neural arches in the lumbar region remain open in 50% of mice unlike in wild-type mice
• however, the neural arches close by P14
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embryo
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• at P10, neural arches in the lumbar region remain open in 50% of mice unlike in wild-type mice
• however, the neural arches close by P14
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digestive/alimentary system
cleft palate
(
J:153789
)
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• in retinoic acid treated mice unlike similarly treated wild-type mice
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growth/size/body
cleft palate
(
J:153789
)
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• in retinoic acid treated mice unlike similarly treated wild-type mice
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