About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stk3+
wild type
MGI:2440881
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Stk3tm1.1Jav/Stk3+
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi 		involves: 129 * C57BL/6 MGI:4411987
cx2
 		Stk3tm1.1Yy/Stk3+
Stk4tm1.1Yy/Stk4tm1.1Yy 		involves: C57BL/6 * CBA MGI:4422185


Genotype
MGI:4411987
cx1
Allelic
Composition		 Stk3tm1.1Jav/Stk3+
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3tm1.1Jav mutation (0 available); any Stk3 mutation (47 available)
Stk4Gt(AJ0315)Wtsi mutation (0 available); any Stk4 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
lethargy ( J:153945 )
• starting at 7 months of age

neoplasm
increased hepatocellular carcinoma incidence ( J:153945 )
• highly aggressive hepatocellular carcinomas (HCCs)
• HCCs in 6 out of 7 asymptomatic mice at 7 months old
• Western blotting, PCR analysis of HCCs reveals the absence of wild-type proteins and DNA of both alleles
• mice that show morbidity (13 out of 16 by 15 months old) harbor liver tumors

liver/biliary system
liver hyperplasia ( J:153945 )
• some mice display overgrowth (2- to 4-fold) of the apparently normal liver tissue
increased hepatocellular carcinoma incidence ( J:153945 )
• highly aggressive hepatocellular carcinomas (HCCs)
• HCCs in 6 out of 7 asymptomatic mice at 7 months old
• Western blotting, PCR analysis of HCCs reveals the absence of wild-type proteins and DNA of both alleles
• mice that show morbidity (13 out of 16 by 15 months old) harbor liver tumors

growth/size/body
liver hyperplasia ( J:153945 )
• some mice display overgrowth (2- to 4-fold) of the apparently normal liver tissue




Genotype
MGI:4422185
cx2
Allelic
Composition		 Stk3tm1.1Yy/Stk3+
Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3tm1.1Yy mutation (0 available); any Stk3 mutation (47 available)
Stk4tm1.1Yy mutation (0 available); any Stk4 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to induced morbidity/mortality ( J:156541 )
• following adenoviral cre injection mice are protected from TNF alpha or Jo-2 antibody (a Fas agonist) induced mortality

liver/biliary system
abnormal liver physiology ( J:156541 )
• following adenoviral cre injection mice are protected from TNF alpha induced liver damage
decreased hepatocyte apoptosis ( J:156541 )
• following adenoviral cre injection mice are protected from TNF alpha or Jo-2 antibody (a Fas agonist) induced apoptosis

homeostasis/metabolism
decreased circulating alanine transaminase level ( J:156541 )
• following adenoviral cre injection mice are mostly protected from TNF alpha induced increases in ALT levels
decreased circulating aspartate transaminase level ( J:156541 )
• following adenoviral cre injection mice are mostly protected from TNF alpha induced increases in ALT levels
abnormal response/metabolism to endogenous compounds ( J:156541 )
• following adenoviral cre injection mice are protected from TNF alpha induced liver damage

cellular
decreased hepatocyte apoptosis ( J:156541 )
• following adenoviral cre injection mice are protected from TNF alpha or Jo-2 antibody (a Fas agonist) induced apoptosis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory