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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ssbp3+
wild type
MGI:2440733
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Ssbp3Tg(SOD1)1Hssk/Ssbp3+ involves: 129S7/SvEvBrd * C3H/He * C57BL/6 * ICR MGI:3663942
ht2
 		Ssbp3Tg(SOD1)1Hssk/Ssbp3+ involves: C3H/He * C57BL/6 MGI:3663945
cx3
 		Lhx1tm1Bhr/Lhx1+
Ssbp3Tg(SOD1)1Hssk/Ssbp3+ 		involves: 129S7/SvEvBrd * C3H/He * C57BL/6 * ICR MGI:3663940
cx4
 		Ldb1tm1Lmgd/Ldb1+
Ssbp3Tg(SOD1)1Hssk/Ssbp3+ 		involves: C3H/He * C57BL/6 MGI:3663943


Genotype
MGI:3663942
ht1
Allelic
Composition		 Ssbp3Tg(SOD1)1Hssk/Ssbp3+
Genetic
Background		 involves: 129S7/SvEvBrd * C3H/He * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ssbp3Tg(SOD1)1Hssk mutation (0 available); any Ssbp3 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:98485 )
• single heterozygotes from intercrosses with Lhx1tm1Bhr/+ mice appear normal at E9.0-9.5




Genotype
MGI:3663945
ht2
Allelic
Composition		 Ssbp3Tg(SOD1)1Hssk/Ssbp3+
Genetic
Background		 involves: C3H/He * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ssbp3Tg(SOD1)1Hssk mutation (0 available); any Ssbp3 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:98485 )
• some single heterozygotes from intercrosses with Ldb1tm1Lgmd/+ mice display mild growth retardation and mild microcephaly at E9.0-9.5




Genotype
MGI:3663940
cx3
Allelic
Composition		 Lhx1tm1Bhr/Lhx1+
Ssbp3Tg(SOD1)1Hssk/Ssbp3+
Genetic
Background		 involves: 129S7/SvEvBrd * C3H/He * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx1tm1Bhr mutation (2 available); any Lhx1 mutation (21 available)
Ssbp3Tg(SOD1)1Hssk mutation (0 available); any Ssbp3 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
embryonic growth retardation ( J:98485 )
• some double heterozygotes display severe growth retardation and microcephaly
microcephaly ( J:98485 )
• double heterozygotes display variable degrees of microcephaly; some embryos appear normal, others display microcephaly while another subset show microcephaly and severe growth retardation

embryo
failure of initiation of embryo turning ( J:98485 )
• the most severely affected double heterozygotes fail to undergo embryonic turning
embryonic growth retardation ( J:98485 )
• some double heterozygotes display severe growth retardation and microcephaly




Genotype
MGI:3663943
cx4
Allelic
Composition		 Ldb1tm1Lmgd/Ldb1+
Ssbp3Tg(SOD1)1Hssk/Ssbp3+
Genetic
Background		 involves: C3H/He * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldb1tm1Lmgd mutation (0 available); any Ldb1 mutation (33 available)
Ssbp3Tg(SOD1)1Hssk mutation (0 available); any Ssbp3 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
embryonic growth retardation ( J:98485 )
• some double heterozygotes show varying degrees of growth retardation
microcephaly ( J:98485 )
• some double heterozygotes display varying degrees of microcephaly

embryo
embryonic growth retardation ( J:98485 )
• some double heterozygotes show varying degrees of growth retardation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory