Analysis Tools
behavior/neurological
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• mice develop hindlimb clasping after 2 months of age
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• 4 month old males perform poorly in the pole test, a test of basal ganglia-related movement control
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• mice perform poorly in the rotarod with a shorter latency to fall than wild-type mice at 4 months of age
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• 4 month old males perform poorly in the cylinder test of rearing
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• mice show poor negative geotaxis performance at 4 months of age
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cellular
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• 12 month old brains show gliosis and accumulation of ubiquitin-positive material in the neuropil and neurons
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• mouse embryonic fibroblasts show reduced capacity to degrade amyloid beta peptides
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• isolated brain and liver mitochondria show impaired degradation rate of amyloid beta(1-42)
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homeostasis/metabolism
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• amyloid deposits are seen in the brains of 4, 6, and 12 month old males
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• reduction in carbon dioxide production at 4 months of age
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• reduction in oxygen consumption at 4 months of age
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• mice show a reduction in heat production over 36 hours of observation
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nervous system
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• 12 month old brains show gliosis and accumulation of ubiquitin-positive material in the neuropil and neurons
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• amyloid deposits are seen in the brains of 4, 6, and 12 month old males
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• mild neuronal loss at 12 months of age
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