About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Kmt2b+
wild type
MGI:2440280
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Kmt2btm2.1Afst/Kmt2b+ involves: 129 * C57BL/6 MGI:4867490
ht2
Kmt2btm1Afst/Kmt2b+ involves: 129P2/OlaHsd MGI:5532305
ht3
Kmt2bGena263/Kmt2b+ involves: BALB/c * C3H/HeH MGI:5532301
ht4
Kmt2bm1H/Kmt2b+ involves: BALB/c * C3H/HeH MGI:5532303


Genotype
MGI:4867490
ht1
Allelic
Composition
Kmt2btm2.1Afst/Kmt2b+
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2btm2.1Afst mutation (0 available); any Kmt2b mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• lower cumulative number of pups from mutant females over a 6-month period than that of controls

embryo
• few embryos reach the blastocyst stage in embryo cultures




Genotype
MGI:5532305
ht2
Allelic
Composition
Kmt2btm1Afst/Kmt2b+
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2btm1Afst mutation (0 available); any Kmt2b mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• in response to glucose challenge
• in fasted mice and during intraperitoneal glucose tolerance test

adipose tissue

liver/biliary system
N
• mice exhibit normal liver weight

endocrine/exocrine glands
• in response to glucose challenge




Genotype
MGI:5532301
ht3
Allelic
Composition
Kmt2bGena263/Kmt2b+
Genetic
Background
involves: BALB/c * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2bGena263 mutation (0 available); any Kmt2b mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• in response to glucose challenge
• in free-fed mice (J:79719)
• in fasted mice and during intraperitoneal glucose tolerance test (J:203736)

adipose tissue
• at 12, but not 8 or 18, weeks

growth/size/body

liver/biliary system
• ballooning hepatocyte degeneration

endocrine/exocrine glands
• in response to glucose challenge




Genotype
MGI:5532303
ht4
Allelic
Composition
Kmt2bm1H/Kmt2b+
Genetic
Background
involves: BALB/c * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2bm1H mutation (0 available); any Kmt2b mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• in response to glucose challenge
• in fasted mice and during intraperitoneal glucose tolerance test

adipose tissue

liver/biliary system

endocrine/exocrine glands
• in response to glucose challenge

growth/size/body





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
01/20/2026
MGI 6.24
The Jackson Laboratory