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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gadd45g+
wild type
MGI:2440153
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Gadd45gtm1Jni/Gadd45g+
Map3k4tm1Flv/Map3k4+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J MGI:5461495
cx2
 		Gadd45gtm1Jni/Gadd45g+
X/SryAKR/J 		involves: 129P2/OlaHsd * AKR/J * C57BL/6J MGI:5461496
cx3
 		Gadd45gtm1Jni/Gadd45g+
X/SryAKR/J
Tg(Map3k4)#Agre/0 		involves: 129P2/OlaHsd * AKR/J * C57BL/6J MGI:5461497


Genotype
MGI:5461495
cx1
Allelic
Composition		 Gadd45gtm1Jni/Gadd45g+
Map3k4tm1Flv/Map3k4+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gadd45gtm1Jni mutation (0 available); any Gadd45g mutation (11 available)
Map3k4tm1Flv mutation (1 available); any Map3k4 mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal testis development ( J:191096 )
• significant numbers of Stra8-positive meiotic germ cells are detectable at the poles of XY gonads at E14.5 indicating a activation of ovarian pathways

reproductive system
abnormal testis development ( J:191096 )
• significant numbers of Stra8-positive meiotic germ cells are detectable at the poles of XY gonads at E14.5 indicating a activation of ovarian pathways




Genotype
MGI:5461496
cx2
Allelic
Composition		 Gadd45gtm1Jni/Gadd45g+
X/SryAKR/J
Genetic
Background		 involves: 129P2/OlaHsd * AKR/J * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gadd45gtm1Jni mutation (0 available); any Gadd45g mutation (11 available)
SryAKR/J mutation (6 available); any Sry mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal testis development ( J:191096 )
• severe disruption of testis determination
ovotestis ( J:191096 )
• about 50% of XY mice develop ovotestes with varying degrees of testicular tissue at E14.5
primary sex reversal ( J:191096 )
• about 50% of XY mice develop gonads with ovarian morphology at E14.5

endocrine/exocrine glands
abnormal testis development ( J:191096 )
• severe disruption of testis determination




Genotype
MGI:5461497
cx3
Allelic
Composition		 Gadd45gtm1Jni/Gadd45g+
X/SryAKR/J
Tg(Map3k4)#Agre/0
Genetic
Background		 involves: 129P2/OlaHsd * AKR/J * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gadd45gtm1Jni mutation (0 available); any Gadd45g mutation (11 available)
SryAKR/J mutation (6 available); any Sry mutation (54 available)
Tg(Map3k4)#Agre mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:191096 )
N
• testis determination and development in XY mice are similar to wild-type XY controls, unlike in mice not carrying the transgene




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory