Phenotypes associated with this allele

• Allele Symbol: Arid1a⁺
• Allele Name: wild type
• Allele ID: MGI:2439928
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Arid1a^tm1.1Mag/Arid1a^+ Gt(ROSA)26Sor^tm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor^+	involves: 129S6/SvEvTac * CD-1	MGI:5784679
cn2	Arid1a^tm1.1Mag/Arid1a^+ H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: C57BL/6J * CBA/J	MGI:5784729

Genotype
MGI:5784679

cn1

• Allelic Composition: Arid1a^tm1.1Mag/Arid1a⁺; Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S6/SvEvTac * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal ovary morphology ( J:219794 )

♀ • 5 of 7 mice injected with an adenovirus expressing cre recombinase (AdCre) in the ovarian bursa exhibit ovarian surface epithelium hyperplasia

neoplasm

neoplasm ( J:219794 )

♀N • however, intrabursally AdCre injected mice do not form ovarian tumors

reproductive system

abnormal ovary morphology ( J:219794 )

♀ • 5 of 7 mice injected with an adenovirus expressing cre recombinase (AdCre) in the ovarian bursa exhibit ovarian surface epithelium hyperplasia

Genotype
MGI:5784729

cn2

• Allelic Composition: Arid1a^tm1.1Mag/Arid1a⁺; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: C57BL/6J * CBA/J

craniofacial

small temporal bone squamous part ( J:231470 )

• smaller squamosal bones

short premaxilla ( J:231470 )

abnormal palatine bone morphology ( J:231470 )

• the anterior palatine length is reduced

short snout ( J:231470 )

lowered ear position ( J:231470 )

growth/size/body

short snout ( J:231470 )

lowered ear position ( J:231470 )

abnormal body composition ( J:231470 )

• body mass is lower

• however, mice show similar intercanthal distance and molar width as wild-type mice, suggesting that craniofacial defects are not due to proportional body size differences

hearing/vestibular/ear

lowered ear position ( J:231470 )

skeleton

small temporal bone squamous part ( J:231470 )

• smaller squamosal bones

short premaxilla ( J:231470 )

abnormal palatine bone morphology ( J:231470 )

• the anterior palatine length is reduced

vision/eye

enophthalmos ( J:231470 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Coffin-Siris syndrome		DOID:1925	OMIM:PS135900	J:231470