All Phenotypes Nr2f2<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nr2f2⁺
wild type
MGI:2439790

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Nr2f2^tm1Tsa/Nr2f2⁺	either: 129S7/SvEvBrd or C57BL/6 or (involves: 129S7/SvEvBrd * C57BL/6 * ICR)	MGI:3042232
ht2	Nr2f2^tm1Tsa/Nr2f2⁺	involves: 129S7/SvEvBrd * C57BL/6	MGI:3717608
cn3	Nr2f2^tm1Vco/Nr2f2⁺ Tg(Ins2-cre)25Mgn/0	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA	MGI:3578329
cn4	Nr2f1^tm2.1Mjts/Nr2f1^tm2.1Mjts Nr2f2^tm2.1Tsa/Nr2f2⁺ Tg(rx3-icre)1Mjam/0	involves: 129S7/SvEvBrd	MGI:4439074

Allelic Composition	Nr2f2^tm1Tsa/Nr2f2⁺
Genetic Background	either: 129S7/SvEvBrd or C57BL/6 or (involves: 129S7/SvEvBrd * C57BL/6 * ICR)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2f2^tm1Tsa mutation (0 available); any Nr2f2 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:54469 )

• approximately two-thirds of heterozygous null mice died before weaning at 21 days postpartum

• poor postnatal viability was confirmed in multiple genetic backgrounds

cardiovascular system

hemorrhage ( J:54469 )

• at E9.5, approximately 5% of heterozygotes exhibited a similar hemorrhagic phenotype as homozygotes

growth/size/body

decreased body size ( J:54469 )

• heterozygous null mice were one-third smaller than wild-type mice by 5 days of birth

Allelic Composition	Nr2f2^tm1Tsa/Nr2f2⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2f2^tm1Tsa mutation (0 available); any Nr2f2 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal ovary morphology ( J:100400 )

• ovaries are less dilated than in wild-type mice

• vascularization of ovaries is reduced

abnormal uterine horn morphology ( J:100400 )

• following treatment with a decidual stimulus, wet weight of the treated horn was less than that of the untreated one

delayed vaginal opening ( J:100400 )

• at 30.6 days compared to 27.9 days in wild-type mice

prolonged diestrus ( J:100400 )

absent estrus ( J:100400 )

• no obvious estrus phase is observed

prolonged metestrus ( J:100400 )

absent estrous cycle ( J:100400 )

• mice lack an obvious estrus phase with prolonged disestrus and metestrus

reduced female fertility ( J:100400 )

decreased litter size ( J:100400 )

• second and third litter sizes are decreased

growth/size/body

postnatal growth retardation ( J:100400 )

homeostasis/metabolism

decreased circulating progesterone level ( J:100400 )

endocrine/exocrine glands

abnormal ovary morphology ( J:100400 )

• ovaries are less dilated than in wild-type mice

• vascularization of ovaries is reduced

Allelic Composition	Nr2f2^tm1Vco/Nr2f2⁺ Tg(Ins2-cre)25Mgn/0
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2f2^tm1Vco mutation (0 available); any Nr2f2 mutation (28 available)
Tg(Ins2-cre)25Mgn mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:98195 )

decreased insulin secretion ( J:98195 )

• virtually no insulin release in response to glucose challenge

increased insulin secretion ( J:98195 )

• slightly higher levels of release under basal conditions

decreased circulating glucose level ( J:98195 )

• slightly lower plasma glucose levels when fasted

• glucose levels normal when fed

increased circulating insulin level ( J:98195 )

• higher plasma insulin levels whether fed or fasted

• plasma insulin/glucagons ratio increased about 2X

• 20 minutes after glucose challenge, insulin levels are lower than in controls

impaired glucose tolerance ( J:98195 )

• glucose intolerant when tested on animals fasted overnight

• very high initial glucose levels after glucose challenge

insulin resistance ( J:98195 )

abnormal lipid level ( J:98195 )

increased circulating triglyceride level ( J:98195 )

• levels remain elevated when fed

decreased fatty acids level ( J:98195 )

• decreased free fatty acid levels when fasted

endocrine/exocrine glands

decreased insulin secretion ( J:98195 )

• virtually no insulin release in response to glucose challenge

increased insulin secretion ( J:98195 )

• slightly higher levels of release under basal conditions

Allelic Composition	Nr2f1^tm2.1Mjts/Nr2f1^tm2.1Mjts Nr2f2^tm2.1Tsa/Nr2f2⁺ Tg(rx3-icre)1Mjam/0
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2f1^tm2.1Mjts mutation (1 available); any Nr2f1 mutation (25 available)
Nr2f2^tm2.1Tsa mutation (0 available); any Nr2f2 mutation (28 available)
Tg(rx3-icre)1Mjam mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal optic fissure closure ( J:157924 )

coloboma ( J:157924 )

• bilaterally open optic fissure at E14.5

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