All Phenotypes Kcnq1ot1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kcnq1ot1⁺
wild type
MGI:2439650

Summary

14 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Kcnq1ot1^tm1.1Ckan/Kcnq1ot1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * M. spretus	MGI:4830275
ht2	Kcnq1ot1^tm1Tilg/Kcnq1ot1⁺	involves: 129S1/Sv * C57BL/6 * M. spretus	MGI:3773041
ht3	Kcnq1ot1^tm2Tilg/Kcnq1ot1⁺	involves: 129S1/Sv * C57BL/6 * M. spretus	MGI:3773042
ht4	Kcnq1ot1^tm3Tilg/Kcnq1ot1⁺	involves: 129S1/Sv * C57BL/6 * M. spretus	MGI:3773043
ht5	Kcnq1ot1^tm4Tilg/Kcnq1ot1⁺	involves: 129S1/Sv * C57BL/6 * M. spretus	MGI:3773044
ht6	Kcnq1ot1^tm2Tilg/Kcnq1ot1⁺	involves: 129S1/Sv * M. spretus	MGI:4830276
ht7	Kcnq1ot1^tm2Mjh/Kcnq1ot1⁺	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:3772669
ht8	Kcnq1ot1^tm3Mjh/Kcnq1ot1⁺	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:3772670
ht9	Kcnq1ot1^tm1.1Mjh/Kcnq1ot1⁺	involves: 129S4/SvJae * C57BL/6J * FVB/N	MGI:2451332
cn10	Kcnq1ot1^tm2.1Ckan/Kcnq1ot1⁺ Meox2^tm1(cre)Sor/Meox2⁺	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SD7	MGI:5431828
cn11	Kcnq1ot1^tm2.1Ckan/Kcnq1ot1⁺ Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SD7	MGI:5431829
cx12	Cdkn1c^tm1Sje/Cdkn1c⁺ Kcnq1ot1^tm1Tilg/Kcnq1ot1⁺	involves: 129 * C57BL/6	MGI:3773051
cx13	Kcnq1ot1^tm1.1Mjh/Del(7Ins2-Tel)1Lef	involves: 129 * C57BL/6 * ICR	MGI:3772940
cx14	Ascl2^tm1Alj/Ascl2⁺ Kcnq1ot1^tm1.1Mjh/Kcnq1ot1⁺	involves: 129 * C57BL/6 * ICR	MGI:3772941

Allelic Composition	Kcnq1ot1^tm1.1Ckan/Kcnq1ot1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * M. spretus

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal DNA methylation ( J:163857 )

• when this allele is inherited paternally, mice exhibit altered DNA methylation at somatically acquired differentially methylated regions compared with wild-type mice

• however, histone modifications to ubiquitously imprinted genes is normal

abnormal imprinting ( J:163857 )

• when this allele is inherited paternally, mice exhibit lineage-specific relaxes imprinting of ubiquitously imprinted genes compared with wild-type mice

• however, genes imprinted only in the placenta are normal

Allelic Composition	Kcnq1ot1^tm1Tilg/Kcnq1ot1⁺
Genetic Background	involves: 129S1/Sv * C57BL/6 * M. spretus

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

weight loss ( J:108700 )

• mice whom paternally inherit the knockout allele display 10-20% decline in weight as they age

cellular

abnormal imprinting ( J:108700 )

• paternal transmission of the deletion leads to the biallelic expression of several genes that are normally only expressed on the maternal allele

• the genes examined that lose imprinting are Axcl2, Kcnq1, Cdkn1c, Slc22a18, Phlda2, Osbpl5

Allelic Composition	Kcnq1ot1^tm2Tilg/Kcnq1ot1⁺
Genetic Background	involves: 129S1/Sv * C57BL/6 * M. spretus

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal imprinting ( J:108700 )

• paternal transmission of the deletion leads to the biallelic expression of several genes that are normally only expressed on the maternal allele

Allelic Composition	Kcnq1ot1^tm3Tilg/Kcnq1ot1⁺
Genetic Background	involves: 129S1/Sv * C57BL/6 * M. spretus

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal imprinting ( J:108700 )

• paternal transmission of the deletion leads to the biallelic expression of several genes that are normally only expressed on the maternal allele

Allelic Composition	Kcnq1ot1^tm4Tilg/Kcnq1ot1⁺
Genetic Background	involves: 129S1/Sv * C57BL/6 * M. spretus

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal imprinting ( J:108700 )

• paternal transmission of the deletion leads to the biallelic expression of several genes that are normally only expressed on the maternal allele

Allelic Composition	Kcnq1ot1^tm2Tilg/Kcnq1ot1⁺
Genetic Background	involves: 129S1/Sv * M. spretus

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal imprinting ( J:163857 )

• when this allele is inherited paternally, mice exhibit disruption in both ubiquitously and placental-specific imprinting compared with wild-type mice

Allelic Composition	Kcnq1ot1^tm2Mjh/Kcnq1ot1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

decreased embryo size ( J:130529 )

• at E15.5, mice that inherit the paternal allele are 11% smaller than wild-type mice

small placenta ( J:130529 )

• at E15.5, mice that inherit the paternal allele exhibit a 14% reduction in placenta compared to wild-type

growth/size/body

decreased embryo size ( J:130529 )

• at E15.5, mice that inherit the paternal allele are 11% smaller than wild-type mice

decreased body size ( J:130529 )

• at E15.5, mice that inherit the paternal allele are 7% smaller than wild-type mice

cellular

abnormal imprinting ( J:130529 )

• expression of several maternally imprinted genes under the control of the Kcnq imprinting control region is disrupted

Allelic Composition	Kcnq1ot1^tm3Mjh/Kcnq1ot1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

genetic imprinting ( J:130529 )

• expression of imprinted genes is normal

Allelic Composition	Kcnq1ot1^tm1.1Mjh/Kcnq1ot1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased embryo size ( J:79882 )

• beginning at E14.5, mice carrying a paternally-inherited allele are smaller than wild-type mice

decreased body weight ( J:79882 )

• mice carrying a paternally-inherited allele weigh 20%-25% less than wild-type littermates up to 6 weeks of age

• weight so internal organs (kidney, liver and lung) are decreased proportional to weight reduction

embryo

decreased embryo size ( J:79882 )

• beginning at E14.5, mice carrying a paternally-inherited allele are smaller than wild-type mice

liver/biliary system

decreased liver weight ( J:79882 )

• in mice carrying a paternally-inherited allele

renal/urinary system

decreased kidney weight ( J:79882 )

• in mice carrying a paternally-inherited allele

respiratory system

decreased lung weight ( J:79882 )

• in mice carrying a paternally-inherited allele

cellular

maternal imprinting ( J:79882 )

• mice do not exhibit defects when the allele is inherited maternally

Allelic Composition	Kcnq1ot1^tm2.1Ckan/Kcnq1ot1⁺ Meox2^tm1(cre)Sor/Meox2⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SD7

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq1ot1^tm2.1Ckan mutation (0 available); any Kcnq1ot1 mutation (0 available)
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal imprinting ( J:185569 )

• loss of imprinting of ubiquitously imprinted genes when the Kcnq1ot1 allele is inherited paternally

• no alteration of imprinting status when the Kcnq1ot1 allele is inherited maternally

growth/size/body

decreased body weight ( J:185569 )

• at 4 weeks of age when the Kcnq1ot1 allele is inherited maternally

postnatal growth retardation ( J:185569 )

Allelic Composition	Kcnq1ot1^tm2.1Ckan/Kcnq1ot1⁺ Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SD7

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq1ot1^tm2.1Ckan mutation (0 available); any Kcnq1ot1 mutation (0 available)
Tg(CAG-cre/Esr1*)5Amc mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal DNA methylation ( J:185569 )

• loss of methylation in the somatic differentially methylated regions following tamoxifen treatment at E8.5 when the Kcnq1ot1 allele is inherited paternally

abnormal imprinting ( J:185569 )

• loss of imprinting of ubiquitously imprinted genes following tamoxifen treatment at E8.5 when the Kcnq1ot1 allele is inherited paternally

• however, silencing of placental-specific imprinted genes is variably maintained

• no alteration of imprinting status when the Kcnq1ot1 allele is inherited maternally

Allelic Composition	Cdkn1c^tm1Sje/Cdkn1c⁺ Kcnq1ot1^tm1Tilg/Kcnq1ot1⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1c^tm1Sje mutation (1 available); any Cdkn1c mutation (19 available)
Kcnq1ot1^tm1Tilg mutation (0 available); any Kcnq1ot1 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:108700 )

N	• mice that maternally inherit the mutant Cdkn1c allele do survive to adulthood

cellular

abnormal imprinting ( J:108700 )

• paternal transmission of the deletion mutation leads to the paternal allelic expression of the Cdkn1c gene and prevents the postnatal lethality phenotype associated with Cdkn1c heterozygotes that paternally inherit the wild-type allele

Allelic Composition	Kcnq1ot1^tm1.1Mjh/Del(7Ins2-Tel)1Lef
Genetic Background	involves: 129 * C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:130399 )

N	• no embryonic lethality is observed in mice maternally inheriting the chromosome deletion

cellular

abnormal imprinting ( J:130399 )

• embryonic lethality associated with maternal transmission of the chromosome deletion is prevented by the addition of the targeted mutation due to a lack of paternal imprinting of genes in the distal portion of chromosome 7

Allelic Composition	Ascl2^tm1Alj/Ascl2⁺ Kcnq1ot1^tm1.1Mjh/Kcnq1ot1⁺
Genetic Background	involves: 129 * C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ascl2^tm1Alj mutation (0 available); any Ascl2 mutation (13 available)
Kcnq1ot1^tm1.1Mjh mutation (0 available); any Kcnq1ot1 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:130399 )

N	• no embryonic lethality is observed in mice maternally inheriting the Ascl2^tm1Alj allele

cellular

abnormal imprinting ( J:130399 )

• embryonic lethality associated with maternal transmission of Ascl2^tm1Alj allele is prevented by the addition of the Kcnq1^tm1.1Mjh allele due to a lack of paternal imprinting of genes in the distal portion of chromosome 7

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