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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cpb2+
wild type
MGI:2439564
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		\Cpb2tm1Efp/\Cpb2+
\Plgtm1Dco/\Plgtm1Dco 		involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 MGI:3720818
cx2
 		\Cpb2tm1Efp/\Cpb2+
\Plgtm1Dco/\Plg+ 		involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 MGI:3720825


Genotype
MGI:3720818
cx1
Allelic
Composition		 \Cpb2tm1Efp/\Cpb2+
\Plgtm1Dco/\Plgtm1Dco
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpb2tm1Efp mutation (0 available); any Cpb2 mutation (27 available)
Plgtm1Dco mutation (0 available); any Plg mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal blood coagulation ( J:80114 )
• in an in vitro assay, fibrinolysis activity exhibits an intermediate increase to 29.3%+/-3.4% compared to 2.3%+/-1.1% in Plgtm1Dco homozygotes and 54.9%+/-3.7% in Cpb2tm1Efp Plgtm1Dco homozygotes




Genotype
MGI:3720825
cx2
Allelic
Composition		 \Cpb2tm1Efp/\Cpb2+
\Plgtm1Dco/\Plg+
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpb2tm1Efp mutation (0 available); any Cpb2 mutation (27 available)
Plgtm1Dco mutation (0 available); any Plg mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal blood coagulation ( J:80114 )
• in an in vitro assay, fibrinolysis activity is increased relative to in Plgtm1Dco homozygotes

immune system
abnormal inflammatory response ( J:80114 )
• 72 hours following thioglycollate injection into the peritoneum, recruitment of leukocytes is improved (23.8+/-2.1 x106 leukocytes in the peritoneum compared to 15.0+/-1.3 x106 in Plgtm1Dco heterozygotes and 28.7+/-1.62 x106 in wild-type mice)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory