Phenotypes associated with this allele

• Allele Symbol: Cdc20⁺
• Allele Name: wild type
• Allele ID: MGI:2439365
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Cdc20^tm1.1(KOMP)Vlcg/Cdc20^+	B6N(Cg)-Cdc20^tm1.1(KOMP)Vlcg/J	MGI:5630946
ht2	Cdc20^tm1.1Pzg/Cdc20^+	involves: 129S7/SvEvBrd * C57BL/6	MGI:3851137

Genotype
MGI:5630946

ht1

• Allelic Composition: Cdc20^{tm1.1(KOMP)Vlcg}/Cdc20⁺
• Genetic Background: B6N(Cg)-Cdc20^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 11674A-C9

Data Sources

IMPC Data for Cdc20

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased grip strength ( J:211773 )

♀

IMPC - JAX

cardiovascular system

increased heart weight ( J:211773 )

♂

IMPC - JAX

growth/size/body

increased heart weight ( J:211773 )

♂

IMPC - JAX

homeostasis/metabolism

decreased circulating glucose level ( J:211773 )

♂

IMPC - JAX

increased circulating glucose level ( J:211773 )

♀

IMPC - JAX

increased fasting circulating glucose level ( J:211773 )

♂

IMPC - JAX

improved glucose tolerance ( J:211773 )

♂

IMPC - JAX

Genotype
MGI:3851137

ht2

• Allelic Composition: Cdc20^tm1.1Pzg/Cdc20⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Liver tumor of a Cdc20^tm1.1Pzg/Cdc20⁺ mouse

cellular

aneuploidy ( J:150421 )

• in cultured MEFs as early as passage 3 and in splenocytes from adult mice the percentage of cells with abnormal karyotypes in increased compared to wild-type controls

neoplasm

increased tumor incidence ( J:150421 )

• palpable tumors can be detected by 6.8 months of age and by 24 months half of mutants have tumors compared to only 10% of wild-type controls

• of mice with tumors, 38% have tumors at multiple organ sites

increased hepatoma incidence ( J:150421 )

• 4 of 29 tumors were hepatomas

increased lymphoma incidence ( J:150421 )

• 25 of 29 tumors were lymphomas

liver/biliary system

increased hepatoma incidence ( J:150421 )

• 4 of 29 tumors were hepatomas