All Phenotypes Nphs1<+> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nphs1⁺
wild type
MGI:2439220

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Nphs1^{Gt(pT1Betageo)1Ruiz}/Nphs1⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:2678506
ht2	Nphs1^tm1Afrn/Nphs1⁺	involves: C57BL/6 * DBA	MGI:5691393
cx3	Magi1^tm1Itl/Magi1^tm1Itl Nphs1^tm1Rkl/Nphs1⁺	involves: 129/Sv * C57BL/6	MGI:6379273

Allelic Composition	Nphs1^{Gt(pT1Betageo)1Ruiz}/Nphs1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nphs1^{Gt(pT1Betageo)1Ruiz} mutation (0 available); any Nphs1 mutation (70 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

fused podocyte foot processes ( J:86048 )

• approximately 33% of podocyte foot processes were fused

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
nephrotic syndrome		DOID:1184		J:86048

Allelic Composition	Nphs1^tm1Afrn/Nphs1⁺
Genetic Background	involves: C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nphs1^tm1Afrn mutation (1 available); any Nphs1 mutation (70 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:101977 )

• mice are viable and fertile

Allelic Composition	Magi1^tm1Itl/Magi1^tm1Itl Nphs1^tm1Rkl/Nphs1⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Magi1^tm1Itl mutation (0 available); any Magi1 mutation (175 available)
Nphs1^tm1Rkl mutation (1 available); any Nphs1 mutation (70 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased urine protein level ( J:237632 )

• At approximately 1 year of age

renal/urinary system

increased urine protein level ( J:237632 )

• At approximately 1 year of age

abnormal podocyte morphology ( J:237632 )

• glomeruli affected showed podocyte swelling

abnormal podocyte slit diaphragm morphology ( J:237632 )

• glomeruli affected showed severe podocyte effacement by electron microscopy analyses

decreased podocyte number ( J:237632 )

• glomeruli affected showed podocyte loss

glomerulosclerosis ( J:237632 )

• focal segmental glomerulosclerosis (FSGS) at approximately 1 year of age in 4 of 23 mice

• FSGS lesions were present in 2?8% of glomeruli in affected mice

• FSGS was of variable intensity, ranging from small focal lesions with characteristic synechia formation to more globally appearing lesions

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24