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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Prss16+
wild type
MGI:2439158
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Prss16tm1.1Mal/Prss16+
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraH-Y,TcrbH-Y)1Pas/?
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 MGI:3843960


Genotype
MGI:3843960
cx1
Allelic
Composition
Prss16tm1.1Mal/Prss16+
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraH-Y,TcrbH-Y)1Pas/?
Genetic
Background
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prss16tm1.1Mal mutation (2 available); any Prss16 mutation (41 available)
Rag2tm1Fwa mutation (48 available); any Rag2 mutation (117 available)
Tg(TcraH-Y,TcrbH-Y)1Pas mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• positive but not negative selection is impaired as evidenced by the low number of anti-HY (male antigen) T cells found in female mice
• there is about a 2-fold drop peripheral CD4 T cells for female but not male mice compared to controls
• there is a decrease (greater than 2-fold) in CD4-single positive thymocytes that express the transgenic TCR in female mice
• there is about a 2-fold drop in lymph node cellularity for female but not male mice compared to controls

hematopoietic system
• positive but not negative selection is impaired as evidenced by the low number of anti-HY (male antigen) T cells found in female mice
• there is about a 2-fold drop peripheral CD4 T cells for female but not male mice compared to controls
• there is a decrease (greater than 2-fold) in CD4-single positive thymocytes that express the transgenic TCR in female mice





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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory