Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ank2+ wild type MGI:2439041 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• median survival of 794 days compared with 896 days for wild-type mice
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• with age
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• with age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 N |
• mice exhibit normal social interactions, vocalization, activity levels, and grooming
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• in the reversal phase of a Morris water maze
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• increased branching
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in isoproterenol-treated mice
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• isoproterenol-treated mice exhibit disorganized shifts of the leading pacemaker and competing multiple pacemakers compared with similarly treated wild-type mice
• acetylcholine-treated mice exhibit reduced sensitivity of pacemaker function compared with similarly treated wild-type mice
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• isoproterenol-treated mice exhibit increased heart rate variability, a larger beat-to-beat variability, disorganized shifts of the leading pacemaker, and competing multiple pacemakers compared with similarly treated wild-type mice
• acetylcholine-treated mice exhibit reduced sensitivity of pacemaker function compared with similarly treated wild-type mice
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• mouse embryonic fibroblasts exhibit increased adipogenesis with both increased in adipocyte numbers and enlarged lipid droplets compared with wild-type cells.
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• decreased basal adipocyte glucose uptake
• however, insulin-stimulated uptake is normal
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• mouse embryonic fibroblasts exhibit increased adipogenesis with both increased in adipocyte numbers and enlarged lipid droplets compared with wild-type cells.
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• decreased basal adipocyte glucose uptake
• however, insulin-stimulated uptake is normal
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| sinoatrial node disease | DOID:0050824 | J:163867 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• median survival of 855 days compared with 896 days for wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• slight in the acquisition and reversal phase of a Morris water maze
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• males make small or no territory markings in response to female urine
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• fewer ultrasonic vocalization
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• increased branching
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/25/2025 MGI 6.24 |
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