About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Amelx+
wild type
MGI:2439023
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Amelxem1(IMPC)Ccpcz/Amelx+ C57BL/6N-Amelxem1(IMPC)Ccpcz/Ccpcz MGI:7471859
ht2
 		Amelxtm1Msnd/Amelx+ involves: 129X1/SvJ MGI:3695922
ht3
 		Amelxtm2Msnd/Amelx+ involves: 129X1/SvJ MGI:3695924
ht4
 		AmelxRgsc888/Amelx+ involves: C57BL/6JJcl * DBA/2J MGI:4438260
ht5
 		AmelxRgsc888/Amelx+ involves: C57BL/6JJcl * DBA/2JJcl MGI:3807979


Genotype
MGI:7471859
ht1
Allelic
Composition		 Amelxem1(IMPC)Ccpcz/Amelx+
Genetic
Background		 C57BL/6N-Amelxem1(IMPC)Ccpcz/Ccpcz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amelxem1(IMPC)Ccpcz mutation (1 available); any Amelx mutation (26 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial

growth/size/body
abnormal tooth morphology ( J:211773 )
IMPC - CCP-IMG

hematopoietic system

immune system
enlarged lymph nodes ( J:211773 )
IMPC - CCP-IMG

skeleton




Genotype
MGI:3695922
ht2
Allelic
Composition		 Amelxtm1Msnd/Amelx+
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amelxtm1Msnd mutation (1 available); any Amelx mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal enamel rod pattern ( J:116448 )
• sections of abnormal rod pattern next to sections of normal rod pattern resulting from X inactivation of either the mutant or wild-type allele
brittle teeth ( J:116448 )
• enamel fractures

growth/size/body
abnormal enamel rod pattern ( J:116448 )
• sections of abnormal rod pattern next to sections of normal rod pattern resulting from X inactivation of either the mutant or wild-type allele
brittle teeth ( J:116448 )
• enamel fractures

skeleton
abnormal enamel rod pattern ( J:116448 )
• sections of abnormal rod pattern next to sections of normal rod pattern resulting from X inactivation of either the mutant or wild-type allele
brittle teeth ( J:116448 )
• enamel fractures




Genotype
MGI:3695924
ht3
Allelic
Composition		 Amelxtm2Msnd/Amelx+
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amelxtm2Msnd mutation (1 available); any Amelx mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal enamel rod pattern ( J:116448 )
• sections of abnormal rod pattern next to sections of normal rod pattern resulting from X inactivation of either the mutant or wild-type allele
brittle teeth ( J:116448 )
• enamel fractures

growth/size/body
abnormal enamel rod pattern ( J:116448 )
• sections of abnormal rod pattern next to sections of normal rod pattern resulting from X inactivation of either the mutant or wild-type allele
brittle teeth ( J:116448 )
• enamel fractures

skeleton
abnormal enamel rod pattern ( J:116448 )
• sections of abnormal rod pattern next to sections of normal rod pattern resulting from X inactivation of either the mutant or wild-type allele
brittle teeth ( J:116448 )
• enamel fractures




Genotype
MGI:4438260
ht4
Allelic
Composition		 AmelxRgsc888/Amelx+
Genetic
Background		 involves: C57BL/6JJcl * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
AmelxRgsc888 mutation (0 available); any Amelx mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal incisor morphology ( J:157947 )
• incisors display patchy regions of roughened, chalky white enamel
abnormal incisor color ( J:157947 )
• patchy regions of chalky white enamel
short incisors ( J:157947 )
• the upper and lower incisors are shortened
abnormal enamel morphology ( J:157947 )
• incisors display patchy regions of roughened, chalky white enamel
abnormal ameloblast morphology ( J:157947 )
• occasional small blister like structures of variable size are apparent from the late secretory stage onwards
• within the blister like structures aberrant matrix is present with areas appearing less eosinophilic than the original enamel matrix
abnormal enamel mineralization ( J:157947 )
• decrease in enamel mineral content
• no defect in dentine mineral levels
abnormal enamel rod pattern ( J:157947 )
• by SEM the prismatic structure is less highly ordered with greater inter-prismatic spacing
brittle teeth ( J:157947 )
• shortened with irregular incisal edge

skeleton
abnormal incisor morphology ( J:157947 )
• incisors display patchy regions of roughened, chalky white enamel
abnormal incisor color ( J:157947 )
• patchy regions of chalky white enamel
short incisors ( J:157947 )
• the upper and lower incisors are shortened
abnormal enamel morphology ( J:157947 )
• incisors display patchy regions of roughened, chalky white enamel
abnormal ameloblast morphology ( J:157947 )
• occasional small blister like structures of variable size are apparent from the late secretory stage onwards
• within the blister like structures aberrant matrix is present with areas appearing less eosinophilic than the original enamel matrix
abnormal enamel mineralization ( J:157947 )
• decrease in enamel mineral content
• no defect in dentine mineral levels
abnormal enamel rod pattern ( J:157947 )
• by SEM the prismatic structure is less highly ordered with greater inter-prismatic spacing
brittle teeth ( J:157947 )
• shortened with irregular incisal edge

growth/size/body
abnormal incisor morphology ( J:157947 )
• incisors display patchy regions of roughened, chalky white enamel
abnormal incisor color ( J:157947 )
• patchy regions of chalky white enamel
short incisors ( J:157947 )
• the upper and lower incisors are shortened
short lower incisors ( J:157947 )
short upper incisors ( J:157947 )
abnormal enamel morphology ( J:157947 )
• incisors display patchy regions of roughened, chalky white enamel
abnormal ameloblast morphology ( J:157947 )
• occasional small blister like structures of variable size are apparent from the late secretory stage onwards
• within the blister like structures aberrant matrix is present with areas appearing less eosinophilic than the original enamel matrix
abnormal enamel mineralization ( J:157947 )
• decrease in enamel mineral content
• no defect in dentine mineral levels
abnormal enamel rod pattern ( J:157947 )
• by SEM the prismatic structure is less highly ordered with greater inter-prismatic spacing
reduced enamel thickness ( J:157947 )
brittle teeth ( J:157947 )
• shortened with irregular incisal edge

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
amelogenesis imperfecta type 1E DOID:0110058 OMIM:301200
 J:157947




Genotype
MGI:3807979
ht5
Allelic
Composition		 AmelxRgsc888/Amelx+
Genetic
Background		 involves: C57BL/6JJcl * DBA/2JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
AmelxRgsc888 mutation (0 available); any Amelx mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal enamel morphology ( J:133634 )
• rough tooth surface

growth/size/body
abnormal enamel morphology ( J:133634 )
• rough tooth surface

skeleton
abnormal enamel morphology ( J:133634 )
• rough tooth surface




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory