Phenotypes associated with this allele

• Allele Symbol: Ahcy⁺
• Allele Name: wild type
• Allele ID: MGI:2438997
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ahcy^em1Cya/Ahcy^+	C57BL/6N-Ahcy^em1Cya/Cya	MGI:6840217
ht2	Ahcy^tm1b(EUCOMM)Hmgu/Ahcy^+	C57BL/6N-Ahcy^tm1b(EUCOMM)Hmgu/Tcp	MGI:5756670

Genotype
MGI:6840217

ht1

• Allelic Composition: Ahcy^em1Cya/Ahcy⁺
• Genetic Background: C57BL/6N-Ahcy^em1Cya/Cya

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal vasodilation ( J:298071 )

• in response to precontraction with phenylephrine and relaxation with acetylcholine, mice with or without indomethacin exhibit endothelial dysfunction compared with control mice

• however, relaxation in response to nitroprusside is normal

cellular

oxidative stress ( J:298071 )

homeostasis/metabolism

abnormal nitric oxide homeostasis ( J:298071 )

• reduced aortic concentration in response to precontraction with phenylephrine and relaxation with acetylcholine

muscle

abnormal vasodilation ( J:298071 )

• in response to precontraction with phenylephrine and relaxation with acetylcholine, mice with or without indomethacin exhibit endothelial dysfunction compared with control mice

• however, relaxation in response to nitroprusside is normal

Genotype
MGI:5756670

ht2

• Allelic Composition: Ahcy^{tm1b(EUCOMM)Hmgu}/Ahcy⁺
• Genetic Background: C57BL/6N-Ahcy^{tm1b(EUCOMM)Hmgu}/Tcp
• Cell Lines: HEPD0517_1_E07

Data Sources

IMPC Data for Ahcy

behavior/neurological

increased grip strength ( J:211773 )

♂

IMPC - TCP

hematopoietic system

increased basophil cell number ( J:211773 )

♂

IMPC - TCP

immune system

increased basophil cell number ( J:211773 )

♂

IMPC - TCP