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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adrb2+
wild type
MGI:2438969
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Adrb2tm1Bkk/Adrb2+ involves: 129S1/Sv * 129X1/SvJ MGI:3579023
cn2
 		Adrb2tm1Kry/Adrb2+
Lepob/Lep+
Tg(Col1a1-cre)1Kry/0 		involves: C57BL/6 * C57BL/10J * FVB MGI:3837367


Genotype
MGI:3579023
ht1
Allelic
Composition		 Adrb2tm1Bkk/Adrb2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adrb2tm1Bkk mutation (2 available); any Adrb2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal osteoclast differentiation ( J:97566 )
• decreased number of tartrate-resistant acid phosphatase (TRAP)-positive multi-nucleated osteoclasts, indicating defective osteoclast differentiation
increased bone volume ( J:97566 )
• increased bone volume/tissue volume and bone formation rate, showing a severe high bone mass phenotype at 6 months of age
abnormal bone resorption ( J:97566 )
• increased bone formation rate and decreased bone resorption

hematopoietic system
abnormal osteoclast differentiation ( J:97566 )
• decreased number of tartrate-resistant acid phosphatase (TRAP)-positive multi-nucleated osteoclasts, indicating defective osteoclast differentiation

immune system
abnormal osteoclast differentiation ( J:97566 )
• decreased number of tartrate-resistant acid phosphatase (TRAP)-positive multi-nucleated osteoclasts, indicating defective osteoclast differentiation

cellular
abnormal osteoclast differentiation ( J:97566 )
• decreased number of tartrate-resistant acid phosphatase (TRAP)-positive multi-nucleated osteoclasts, indicating defective osteoclast differentiation




Genotype
MGI:3837367
cn2
Allelic
Composition		 Adrb2tm1Kry/Adrb2+
Lepob/Lep+
Tg(Col1a1-cre)1Kry/0
Genetic
Background		 involves: C57BL/6 * C57BL/10J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adrb2tm1Kry mutation (0 available); any Adrb2 mutation (33 available)
Lepob mutation (5 available); any Lep mutation (19 available)
Tg(Col1a1-cre)1Kry mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating glucose level ( J:145998 )
• mice exhibit postprandial low blood glucose levels compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory