All Phenotypes Actb<+> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Actb^{tm3.1(Sirt1)Npa}/Actb⁺	involves: 129/Sv * C57BL/6 * C57BL/6J	MGI:4456085
ht2	Actb^{tm1(PyVT)Arge}/Actb⁺	involves: 129S1/Sv	MGI:3032630
ht3	Actb^tm2(Tag)Arge/Actb⁺	involves: 129S1/Sv	MGI:3032633
ht4	Actb^tm2Npa/Actb⁺	involves: BALB/c	MGI:3769440
ht5	Actb^tm1Npa/Actb⁺	involves: BALB/cJ	MGI:3770049
cn6	Actb^{tm1(PyVT)Arge}/Actb⁺ Wap^tm1(cre)Arge/Wap⁺	involves: 129S1/Sv	MGI:3032632
cn7	Actb^tm2(Tag)Arge/Actb⁺ Tg(Hsp70-1-cre)1Arge/0	involves: 129S1/Sv * C57BL/6J * CBA	MGI:3032629
cn8	Actb^{tm1(PyVT)Arge}/Actb⁺ Tg(Hsp70-1-cre)1Arge/0	involves: 129S1/Sv * C57BL/6J * CBA	MGI:3032631
cn9	Actb^{tm4(cre/ERT2)Npa}/Actb⁺ Sgpl1^tm1.1Npa/Sgpl1^tm1.1Npa	involves: BALB/cJ * C57BL/6	MGI:5515215
cx10	Actb^{tm1.1(tetO-COP4*/EYFP)Kftnk}/Actb⁺ Tg(Mlc1-tTA)2Rhn/0	involves: 129 * 129S4/SvJaeSor * C57BL/6 * CBA	MGI:5439338
cx11	Actb^{tm3.1(Sirt1)Npa}/Actb⁺ Sirt1^tm1Mcby/Sirt1^tm1Mcby	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J	MGI:4456088

Allelic Composition	Actb^{tm3.1(Sirt1)Npa}/Actb⁺
Genetic Background	involves: 129/Sv * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actb^{tm3.1(Sirt1)Npa} mutation (1 available); any Actb mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:160212 )

• fewer than expected mice are produced (no time of death given)

reproductive system

delayed fertility ( J:160212 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:160212 )

N	• mice exhibit normal levels of circulating triglyceride, glycerol, IGF, IGF-1, lactate, hydrobutyrate, and corticosterone

decreased fasting circulating glucose level ( J:160212 )

• reduced plasma glucose levels in fasted mice at 6 months of age

decreased circulating insulin level ( J:160212 )

• reduced plasma insulin levels in fed mice at 6 months of age

decreased circulating leptin level ( J:160212 )

• at 3 and 12 months

decreased circulating cholesterol level ( J:160212 )

• at 3 and 12 months

decreased circulating HDL cholesterol level ( J:160212 )

decreased circulating LDL cholesterol level ( J:160212 )

decreased circulating free fatty acids level ( J:160212 )

• at 12 months

increased oxygen consumption ( J:160212 )

• at 7 months of age

improved glucose tolerance ( J:160212 )

decreased circulating adiponectin level ( J:160212 )

• at 12 months

behavior/neurological

behavior/neurological phenotype ( J:160212 )

N	• mice exhibit normal baseline physical activity

increased food intake ( J:160212 )

• increase in food consumption normalized to body weight

abnormal motor coordination/balance ( J:160212 )

• mice exhibit improved performance on a rotarod compared with wild-type mice

growth/size/body

decreased body weight ( J:160212 )

adipose tissue

decreased epididymal fat pad weight ( J:160212 )

• at 3 months

Allelic Composition	Actb^{tm1(PyVT)Arge}/Actb⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actb^{tm1(PyVT)Arge} mutation (0 available); any Actb mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:87544 )

neoplasm

increased mammary adenocarcinoma incidence ( J:87544 )

• some post-partum females developed tumors as a result of cre-independent excision of the floxed neo cassette

• lung metastases were observed in some cases

increased hemangioma incidence ( J:87544 )

• associated with cre-independent excision of the floxed neomycin cassette

integument

increased mammary adenocarcinoma incidence ( J:87544 )

• some post-partum females developed tumors as a result of cre-independent excision of the floxed neo cassette

• lung metastases were observed in some cases

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:87544 )

• some post-partum females developed tumors as a result of cre-independent excision of the floxed neo cassette

• lung metastases were observed in some cases

Allelic Composition	Actb^tm2(Tag)Arge/Actb⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actb^tm2(Tag)Arge mutation (0 available); any Actb mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased sarcoma incidence ( J:87544 )

• some females developed tumors as a result of cre-independent excision of the floxed neo cassette

Allelic Composition	Actb^tm2Npa/Actb⁺
Genetic Background	involves: BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actb^tm2Npa mutation (0 available); any Actb mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:129105 )

• mice are smaller than their wild-type counterparts

Allelic Composition	Actb^tm1Npa/Actb⁺
Genetic Background	involves: BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actb^tm1Npa mutation (0 available); any Actb mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:129639 )

• adults have 10% lower body weight

Allelic Composition	Actb^{tm1(PyVT)Arge}/Actb⁺ Wap^tm1(cre)Arge/Wap⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actb^{tm1(PyVT)Arge} mutation (0 available); any Actb mutation (52 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:87544 )

• premature death

neoplasm

increased mammary adenocarcinoma incidence ( J:87544 )

cardiovascular system

decreased cardiac muscle contractility ( J:87544 )

• exhibited by 70% of females (mostly virgins, indicating that this phenotype is associated with cre-independent excision of the floxed neomycin cassette)

muscle

decreased cardiac muscle contractility ( J:87544 )

• exhibited by 70% of females (mostly virgins, indicating that this phenotype is associated with cre-independent excision of the floxed neomycin cassette)

integument

increased mammary adenocarcinoma incidence ( J:87544 )

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:87544 )

Allelic Composition	Actb^tm2(Tag)Arge/Actb⁺ Tg(Hsp70-1-cre)1Arge/0
Genetic Background	involves: 129S1/Sv * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actb^tm2(Tag)Arge mutation (0 available); any Actb mutation (52 available)
Tg(Hsp70-1-cre)1Arge mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased leiomyosarcoma incidence ( J:87544 )

• females exhibited uterine leiomyosacromas around 3 months of age

endocrine/exocrine glands

enlarged seminal vesicle ( J:87544 )

• enlarged due to pronounced hyperplasia of smooth muscle layers

enlarged gallbladder ( J:87544 )

• marked dilation in both males and females due to smooth muscle proliferation

liver/biliary system

enlarged gallbladder ( J:87544 )

• marked dilation in both males and females due to smooth muscle proliferation

muscle

abnormal smooth muscle morphology ( J:87544 )

• smooth muscle hyperproliferation in both males and females

increased leiomyosarcoma incidence ( J:87544 )

• females exhibited uterine leiomyosacromas around 3 months of age

reproductive system

enlarged seminal vesicle ( J:87544 )

• enlarged due to pronounced hyperplasia of smooth muscle layers

abnormal uterus morphology ( J:87544 )

• development of leiomyosarcomas in the uterus

growth/size/body

enlarged gallbladder ( J:87544 )

• marked dilation in both males and females due to smooth muscle proliferation

Allelic Composition	Actb^{tm1(PyVT)Arge}/Actb⁺ Tg(Hsp70-1-cre)1Arge/0
Genetic Background	involves: 129S1/Sv * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actb^{tm1(PyVT)Arge} mutation (0 available); any Actb mutation (52 available)
Tg(Hsp70-1-cre)1Arge mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:87544 )

• death by E6.5

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:199525 )

N	• with tamoxifen treatment mice show normal survival up to 6 months of observation

growth/size/body

growth/size/body region phenotype ( J:199525 )

N	• after tamoxifen treatment mice show normal weight gain up to 6 months of observation

hematopoietic system

increased thymocyte number ( J:199525 )

• thymocytes are enriched in mature single-positive T cells

decreased follicular B cell number ( J:199525 )

• with tamoxifen treatment total numbers are decreased significantly, with no significant change in germinal center B cells

decreased marginal zone B cell number ( J:199525 )

• with tamoxifen treatment total numbers are decreased significantly, with no significant change in germinal center B cells

abnormal regulatory T cell number ( J:199525 )

• with tamoxifen treatment numbers of CD4+Foxp3+ T cells are reduced 3-4 fold in spleen and increased more than 4-fold in lymph nodes with tamoxifen treatment

decreased single-positive T cell number ( J:199525 )

• mice treated with tamoxifen daily for 5 days have decreases in CD4- and CD8-positive T cells by up to 85% two weeks later, lasting for at least 6 months; CD19-positive B cell numbers are unchanged

• at 8 weeks after tamoxifen treatment, splenic populations of CD4- and CD8-positive T cells are sharply reduced

spleen hypoplasia ( J:199525 )

• at 8 weeks after tamoxifen treatment splenic cellularity sharply decreased with significant reductions in CD- and CD8-positive T cells and subpopulations of B cells

immune system

increased thymocyte number ( J:199525 )

• thymocytes are enriched in mature single-positive T cells

decreased follicular B cell number ( J:199525 )

• with tamoxifen treatment total numbers are decreased significantly, with no significant change in germinal center B cells

decreased marginal zone B cell number ( J:199525 )

• with tamoxifen treatment total numbers are decreased significantly, with no significant change in germinal center B cells

abnormal regulatory T cell number ( J:199525 )

• with tamoxifen treatment numbers of CD4+Foxp3+ T cells are reduced 3-4 fold in spleen and increased more than 4-fold in lymph nodes with tamoxifen treatment

decreased single-positive T cell number ( J:199525 )

• at 8 weeks after tamoxifen treatment, splenic populations of CD4- and CD8-positive T cells are sharply reduced

spleen hypoplasia ( J:199525 )

• at 8 weeks after tamoxifen treatment splenic cellularity sharply decreased with significant reductions in CD- and CD8-positive T cells and subpopulations of B cells

abnormal lymph node morphology ( J:199525 )

• with tamoxifen treatment lymph node cell numbers are significantly increased with an increase in CD4- and CD8-positive T cells and total B cell numbers (except germinal center B cells

abnormal type IV hypersensitivity reaction ( J:199525 )

• tamoxifen treated mice are protected from delayed-type hypersensitivity reaction induced by localized challenge with sheep red blood cells

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:199525 )

• tamoxifen treated mice are almost completely protected from MOG-induced EAE

homeostasis/metabolism

abnormal lipid homeostasis ( J:199525 )

• 2 weeks after induction of cre, levels of S1P (Sgpl1 substrate) are increased 4-fold (heart) to 100-fold (spleen/lymph nodes) with no significant increase in the brain or spinal cord; blood concentrations are elevate only 1.6-fold

• ceramide (S1P precursor) is not significantly elevated with Sph (S1P precursor) increased 16-fold

• increase of sphingolipid metabolites is much less pronounce than in constitutive Sgpl1 knockouts

endocrine/exocrine glands

increased thymocyte number ( J:199525 )

• thymocytes are enriched in mature single-positive T cells

Allelic Composition	Actb^{tm1.1(tetO-COP4*/EYFP)Kftnk}/Actb⁺ Tg(Mlc1-tTA)2Rhn/0
Genetic Background	involves: 129 * 129S4/SvJaeSor * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actb^{tm1.1(tetO-COP4*/EYFP)Kftnk} mutation (1 available); any Actb mutation (52 available)
Tg(Mlc1-tTA)2Rhn mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal astrocyte physiology ( J:193127 )

• photostimulated astrocytes release glutamate

abnormal neuron physiology ( J:193127 )

• photostimulated astrocytes release glutamate, which is sufficient to activate AMPA receptors on neighboring Purkinje cells and to induce long-term depression of parallel fiber-to-Purkinje cell synapses through activation of metabotropic glutamate receptors

• neuronal activation by glial stimulation can lead to perturbation of cerebellar modulated motor behavior

cellular

abnormal astrocyte physiology ( J:193127 )

• photostimulated astrocytes release glutamate

Allelic Composition	Actb^{tm3.1(Sirt1)Npa}/Actb⁺ Sirt1^tm1Mcby/Sirt1^tm1Mcby
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actb^{tm3.1(Sirt1)Npa} mutation (1 available); any Actb mutation (52 available)
Sirt1^tm1Mcby mutation (2 available); any Sirt1 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:160212 )

N	• unlike Sirt1^tm1Mcby homozygotes, mice are fertile

growth/size/body

growth/size/body region phenotype ( J:160212 )

N	• unlike Sirt1^tm1Mcby homozygotes, mice exhibit normal body size and weight

vision/eye

vision/eye phenotype ( J:160212 )

N	• unlike Sirt1^tm1Mcby homozygotes, eyelids open

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