All Phenotypes E2f6<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

E2f6⁺
wild type
MGI:2438773

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	E2f6^tm1Sgau/E2f6⁺	involves: 129S4/SvJae * C57BL/6	MGI:3618161
ht2	E2f6^tm1Lees/E2f6⁺	involves: 129S4/SvJae * C57BL/6	MGI:3790809
cx3	Bmi1^tm1Brn/Bmi1⁺ E2f6^tm1Lees/E2f6⁺	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:3790812
cx4	Bmi1^tm1Brn/Bmi1^tm1Brn E2f6^tm1Lees/E2f6⁺	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:3790813

Allelic Composition	E2f6^tm1Sgau/E2f6⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f6^tm1Sgau mutation (0 available); any E2f6 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

lumbar vertebral transformation ( J:106219 )

• the 6th lumbar vertebra is transformed to the 1st sacral vertebra in 40% of heterozygotes

Allelic Composition	E2f6^tm1Lees/E2f6⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f6^tm1Lees mutation (0 available); any E2f6 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

thoracic vertebral transformation ( J:134271 )

• transformation of T13 to L1 is seen in 10% of heterozygous mice

lumbar vertebral transformation ( J:134271 )

• transformation of L6 to S1 is seen in 24% of heterozygous mice

Allelic Composition	Bmi1^tm1Brn/Bmi1⁺ E2f6^tm1Lees/E2f6⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmi1^tm1Brn mutation (2 available); any Bmi1 mutation (33 available)
E2f6^tm1Lees mutation (0 available); any E2f6 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

thoracic vertebral transformation ( J:134271 )

• transformation of T7 to T8 and T13 to L1 are seen in 4% and 50% of double heterozygous mice, respectively

cervical vertebral transformation ( J:134271 )

• partial or complete transformation of C7 to T1 is seen in 42% and 8% of double heterozygous mice, respectively

• transformation of C5 to C6 is seen in 4% of double heterozygous mice

lumbar vertebral transformation ( J:134271 )

• transformation of L6 to S1 is seen in 73% of double heterozygous mice

Allelic Composition	Bmi1^tm1Brn/Bmi1^tm1Brn E2f6^tm1Lees/E2f6⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal vertebrae morphology ( J:134271 )

• small extra bone present above C1 in 62% of compound mutant mice

thoracic vertebral transformation ( J:134271 )

• transformation of T7 to T8 and T13 to L1 are seen in 77% and 85% of compound mutant mice, respectively

cervical vertebral transformation ( J:134271 )

• transformation of C1 to C2, C5 to C6, and C7 to T1 are seen in 85%, 23%, and 31% of compound mutant mice, respectively

• partial transformation of C7 to T1 is seen in 77% of compound mutant mice

lumbar vertebral transformation ( J:134271 )

• transformation of L6 to S1 is seen in 92% of compound mutant mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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